表皮干细胞：伤口愈合过程中与皮肤微环境的相互作用

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2024-10-21 DOI:10.1016/j.mocell.2024.100138

Yun Ha Hur

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引用次数: 0

摘要

皮肤每天都在进行新陈代谢，同时经常受到损伤的挑战。皮肤的伤口愈合过程是一连串动态事件，涉及各种细胞类型和信号通路。表皮干细胞（EpdSCs）是皮肤组织中的组织驻留干细胞，具有自我更新和分化的特殊能力，是这一复杂过程的核心。在这一过程中，表皮干细胞与组织微环境积极互动，这对正常的再上皮化和皮肤屏障恢复至关重要。本综述介绍了 EpdSCs 与其周围环境中各种成分（包括 ECM/成纤维细胞、血管/内皮细胞和免疫细胞）之间错综复杂的相互作用，以及它们在组织修复中的作用。

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Epidermal stem cells: Interplay with the skin microenvironment during wound healing

Skin undergoes everyday turnover while often challenged by injuries. The wound healing process in the skin is a dynamic sequence of events that involves various cell types and signaling pathways. Epidermal stem cells (EpdSCs), the tissue-resident stem cells in the skin tissue, are at the center of this complicated process due to their special ability to self-renew and differentiate. During this process, EpdSCs interact actively with the tissue microenvironment, which is essential for proper re-epithelialization and skin barrier restoration. This review describes the intricate interplays between EpdSCs and various components of their surroundings, including extracellular matrix/fibroblasts, vasculature/endothelial cells, and immune cells, as well as their roles in tissue repair.

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.