芦荟对皮肤及其寄生菌的影响:芦荟甘露聚糖在治疗痤疮丙酸杆菌引起的痤疮中的作用

IF 4.1 2区 生物学 Q2 MICROBIOLOGY
Suraj Pal, Mayank Raj, Medha Singh, Kumar Saurav, Chetan Paliwal, Subhasish Saha, Anil Kumar Sharma, Manoj Singh
{"title":"芦荟对皮肤及其寄生菌的影响:芦荟甘露聚糖在治疗痤疮丙酸杆菌引起的痤疮中的作用","authors":"Suraj Pal, Mayank Raj, Medha Singh, Kumar Saurav, Chetan Paliwal, Subhasish Saha, Anil Kumar Sharma, Manoj Singh","doi":"10.3390/microorganisms12102070","DOIUrl":null,"url":null,"abstract":"<p><p><i>Aloe vera</i> is one of the most significant therapeutical plant species that belongs to the family Liliaceae. <i>Aloe vera</i> is composed of a high amount of water, with the remainder being dry matter. The dry matter contains a lot of bioactive compounds like carbohydrates, fats, and enzymes, with various therapeutic and antimicrobial properties. It can enhance the proliferation of cells and prevent cell damage by anti-oxidative properties (stimulating the secretion of superoxide dismutase and peroxidase). Human skin is colonized by microbes like fungi (<i>Candida albicans</i>), bacteria (<i>Propionibacterium acnes</i>, <i>Staphylococcus aureus</i>), and mites. These commensals are responsible for skin characteristics such as acidic pH, the pungent smell of sweat, etc. Human fetuses lack skin microbiota, and their skin is colonized after birth. Commensals present on the skin have a crucial role in training the human immune system against other pathogenic microbes. <i>Propionibacterium acnes</i> act as an opportunistic pathogen when the balance between the commensals is disturbed. We also emphasize the recent progress in identifying the aloe metabolite biosynthesis pathways and the associated enzyme machinery. The hyperproliferation of <i>Propionibacterium acnes</i> causes acne, and acemannan plays a significant role in its cure. Hence, we need to consider a new treatment approach based on the root cause of this dysbiosis.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510295/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Effect of <i>Aloe vera</i> on Skin and Its Commensals: Contribution of Acemannan in Curing Acne Caused by <i>Propionibacterium acnes</i>.\",\"authors\":\"Suraj Pal, Mayank Raj, Medha Singh, Kumar Saurav, Chetan Paliwal, Subhasish Saha, Anil Kumar Sharma, Manoj Singh\",\"doi\":\"10.3390/microorganisms12102070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Aloe vera</i> is one of the most significant therapeutical plant species that belongs to the family Liliaceae. <i>Aloe vera</i> is composed of a high amount of water, with the remainder being dry matter. The dry matter contains a lot of bioactive compounds like carbohydrates, fats, and enzymes, with various therapeutic and antimicrobial properties. It can enhance the proliferation of cells and prevent cell damage by anti-oxidative properties (stimulating the secretion of superoxide dismutase and peroxidase). Human skin is colonized by microbes like fungi (<i>Candida albicans</i>), bacteria (<i>Propionibacterium acnes</i>, <i>Staphylococcus aureus</i>), and mites. These commensals are responsible for skin characteristics such as acidic pH, the pungent smell of sweat, etc. Human fetuses lack skin microbiota, and their skin is colonized after birth. Commensals present on the skin have a crucial role in training the human immune system against other pathogenic microbes. <i>Propionibacterium acnes</i> act as an opportunistic pathogen when the balance between the commensals is disturbed. We also emphasize the recent progress in identifying the aloe metabolite biosynthesis pathways and the associated enzyme machinery. The hyperproliferation of <i>Propionibacterium acnes</i> causes acne, and acemannan plays a significant role in its cure. Hence, we need to consider a new treatment approach based on the root cause of this dysbiosis.</p>\",\"PeriodicalId\":18667,\"journal\":{\"name\":\"Microorganisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510295/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microorganisms\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3390/microorganisms12102070\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microorganisms","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/microorganisms12102070","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

芦荟属于百合科,是最重要的治疗植物物种之一。芦荟由大量水分组成,其余部分为干物质。干物质中含有大量生物活性化合物,如碳水化合物、脂肪和酶,具有各种治疗和抗菌特性。它能促进细胞增殖,并通过抗氧化特性(刺激超氧化物歧化酶和过氧化物酶的分泌)防止细胞受损。人体皮肤上有真菌(白色念珠菌)、细菌(痤疮丙酸杆菌、金黄色葡萄球菌)和螨虫等微生物。这些共生菌是皮肤酸碱度、汗味等皮肤特征的形成原因。人类胎儿缺乏皮肤微生物群,他们的皮肤在出生后就开始定植。皮肤上的共生菌在训练人体免疫系统抵御其他病原微生物方面起着至关重要的作用。当共生菌之间的平衡被打破时,痤疮丙酸杆菌就会成为机会性病原体。我们还强调了最近在确定芦荟代谢物生物合成途径和相关酶机制方面取得的进展。痤疮丙酸杆菌的过度增殖会导致痤疮,而芦荟甘露聚糖在治疗痤疮方面发挥着重要作用。因此,我们需要考虑一种基于这种菌群失调根源的新治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Aloe vera on Skin and Its Commensals: Contribution of Acemannan in Curing Acne Caused by Propionibacterium acnes.

Aloe vera is one of the most significant therapeutical plant species that belongs to the family Liliaceae. Aloe vera is composed of a high amount of water, with the remainder being dry matter. The dry matter contains a lot of bioactive compounds like carbohydrates, fats, and enzymes, with various therapeutic and antimicrobial properties. It can enhance the proliferation of cells and prevent cell damage by anti-oxidative properties (stimulating the secretion of superoxide dismutase and peroxidase). Human skin is colonized by microbes like fungi (Candida albicans), bacteria (Propionibacterium acnes, Staphylococcus aureus), and mites. These commensals are responsible for skin characteristics such as acidic pH, the pungent smell of sweat, etc. Human fetuses lack skin microbiota, and their skin is colonized after birth. Commensals present on the skin have a crucial role in training the human immune system against other pathogenic microbes. Propionibacterium acnes act as an opportunistic pathogen when the balance between the commensals is disturbed. We also emphasize the recent progress in identifying the aloe metabolite biosynthesis pathways and the associated enzyme machinery. The hyperproliferation of Propionibacterium acnes causes acne, and acemannan plays a significant role in its cure. Hence, we need to consider a new treatment approach based on the root cause of this dysbiosis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Microorganisms
Microorganisms Medicine-Microbiology (medical)
CiteScore
7.40
自引率
6.70%
发文量
2168
审稿时长
20.03 days
期刊介绍: Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信