寄生虫与微生物群:双重相互作用与治疗前景。

IF 4.1 2区 生物学 Q2 MICROBIOLOGY
Hayat S Al-Rashidi, Eman S El-Wakil
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引用次数: 0

摘要

人体肠道内有多种活跃的细菌群落,它们以共生的方式为肠道内壁的生理、代谢和免疫提供支持。然而,寄生虫(蠕虫和原生动物)的动态群落可能与肠道内的微生物群共享一个栖息地。微生物群和寄生虫都能显著改变肠道的物理和免疫环境,从而产生多种相互作用机制。研究这一领域对于了解寄生虫病的发病机制至关重要。此外,肠道微生物群和肠道寄生虫可能相互影响,并与宿主免疫相互作用,从而减轻或加重疾病。这些相互作用可改变寄生虫和微生物群的致病性,从而改变感染结果和整体疾病状况。寄生虫和微生物群的相互作用通过多种机制发生,包括胃肠道微环境的物理改变以及适应性和先天性免疫反应。通过调节微生物群,了解肠道寄生虫与微生物群相互作用的机制和后果,可以改善寄生虫感染和微生物群失调的治疗。因此,可以引入包括益生菌在内的新生物治疗工具,特别是在出现耐药性和不良反应的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parasites and Microbiota: Dual Interactions and Therapeutic Perspectives.

The human gut hosts a diverse and active community of bacteria that symbiotically support the physiology, metabolism, and immunity of the intestinal lining. Nevertheless, a dynamic community of parasites (helminths and protozoa) may share a habitat with gut-dwelling microbiota. Both microbiota and parasites can significantly change the physical and immunological environment of the gut, thus generating several mechanisms of interaction. Studying this field is crucial for understanding the pathogenesis of parasitic diseases. Additionally, intestinal microbiota and gut-dwelling parasites may interact with each other and with the host immunity to alleviate or exacerbate the disease. These interactions can alter the pathogenicity of both parasites and microbiota, thereby changing the infection outcomes and the overall disease profile. Parasites and microbiota interactions occur via several mechanisms, including physical alteration in both the gastrointestinal microenvironment and the adaptive and innate immune responses. By modulating the microbiota, treating parasitic infections and microbiota dysbiosis may be improved through knowing the mechanisms and consequences of the interactions between intestinal parasites and the microbiota. Thus, new biological tools of treatment including probiotics can be introduced, particularly with the emergence of drug resistance and adverse effects.

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来源期刊
Microorganisms
Microorganisms Medicine-Microbiology (medical)
CiteScore
7.40
自引率
6.70%
发文量
2168
审稿时长
20.03 days
期刊介绍: Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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