血脂对多发性大蛛网膜肉芽肿合并症的影响。

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yibing Guo, Zhongao Wang, Meini Gao, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
{"title":"血脂对多发性大蛛网膜肉芽肿合并症的影响。","authors":"Yibing Guo, Zhongao Wang, Meini Gao, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng","doi":"10.1186/s12944-024-02341-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research.</p><p><strong>Methods: </strong>The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs.</p><p><strong>Results: </strong>A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs.</p><p><strong>Conclusions: </strong>TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514773/pdf/","citationCount":"0","resultStr":"{\"title\":\"The effect of blood lipids on the comorbidity of multiple large arachnoid granulations.\",\"authors\":\"Yibing Guo, Zhongao Wang, Meini Gao, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng\",\"doi\":\"10.1186/s12944-024-02341-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research.</p><p><strong>Methods: </strong>The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs.</p><p><strong>Results: </strong>A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs.</p><p><strong>Conclusions: </strong>TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.</p>\",\"PeriodicalId\":18073,\"journal\":{\"name\":\"Lipids in Health and Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514773/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lipids in Health and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12944-024-02341-4\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-024-02341-4","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:目前,有关蛛网膜肉芽肿(AG)增大形成机制的研究尚属空白。本研究探讨了血脂异常对多发性大蛛网膜肉芽(LAG)形成的影响:研究对象包括被诊断为与 LAG 相关的脑静脉窦狭窄(CVSS)患者。通过高分辨率黑血磁共振成像评估 LAG 的数量。研究人员还探讨了血脂与多发性 LAG 之间的关系,以评估血脂异常对多发性 LAG 形成的影响:结果:共纳入 163 名确诊为 LAG 的参与者。多发性 LAGs 组的总胆固醇(TC)(P = 0.004)和低密度脂蛋白胆固醇(LDL-c)(P = 0.01)水平高于非多发性 LAGs 组。多变量逻辑回归分析显示,TC(几率比(OR),2.19;95% 置信区间(CI),1.26-3.80;P = 0.006)和 LDL-c(OR,2.18;95% CI,1.16-4.07;P = 0.02)与多重 LAGs 独立相关:TC和LDL-c与多种LAGs独立相关,表明血脂异常可能是导致CVSS的潜在原因之一。因此,对 LAG 患者进行血脂监测可能是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of blood lipids on the comorbidity of multiple large arachnoid granulations.

Background: Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research.

Methods: The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs.

Results: A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs.

Conclusions: TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信