血脂对多发性大蛛网膜肉芽肿合并症的影响。

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2024-10-28 DOI:10.1186/s12944-024-02341-4

Yibing Guo, Zhongao Wang, Meini Gao, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng

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引用次数: 0

摘要

背景：目前，有关蛛网膜肉芽肿（AG）增大形成机制的研究尚属空白。本研究探讨了血脂异常对多发性大蛛网膜肉芽（LAG）形成的影响：研究对象包括被诊断为与 LAG 相关的脑静脉窦狭窄（CVSS）患者。通过高分辨率黑血磁共振成像评估 LAG 的数量。研究人员还探讨了血脂与多发性 LAG 之间的关系，以评估血脂异常对多发性 LAG 形成的影响：结果：共纳入 163 名确诊为 LAG 的参与者。多发性 LAGs 组的总胆固醇（TC）（P = 0.004）和低密度脂蛋白胆固醇（LDL-c）（P = 0.01）水平高于非多发性 LAGs 组。多变量逻辑回归分析显示，TC（几率比（OR），2.19；95% 置信区间（CI），1.26-3.80；P = 0.006）和 LDL-c（OR，2.18；95% CI，1.16-4.07；P = 0.02）与多重 LAGs 独立相关：TC和LDL-c与多种LAGs独立相关，表明血脂异常可能是导致CVSS的潜在原因之一。因此，对 LAG 患者进行血脂监测可能是必要的。

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The effect of blood lipids on the comorbidity of multiple large arachnoid granulations.

Background: Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research.

Methods: The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs.

Results: A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs.

Conclusions: TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.