内脏脂质堆积指标与胆结石之间的关系:基于 NHANES 2017-2020 的横断面研究。

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Weigen Wu, Yuchen Pei, Junlong Wang, Qizhi Liang, Wei Chen
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引用次数: 0

摘要

背景:肥胖是导致胆结石形成的一个主要因素。由于早期发现通常可改善预后,我们探讨了内脏脂质堆积指标与胆结石发生之间的关系:这项横断面研究涉及 3224 名成年人。研究人员采用多变量逻辑回归、平滑曲线拟合 (SCF)、阈值效应分析和亚组分析来研究内脏脂肪代谢评分 (METS-VF)、腰围 (WC)、脂质堆积产物 (LAP) 和内脏脂肪指数 (VAI) 与胆结石之间的关系。利用最小绝对收缩和选择操作器(LASSO)回归分析确定关键因素,然后利用这些因素构建提名图模型。然后利用接收器操作特征曲线确定该模型在检测胆结石方面的诊断效果:结果:内脏脂质堆积指标与胆结石的可能性密切相关。使用 SCF 确定了 METS-VF、WC、LAP 和 VAI 与胆结石的特定饱和效应。这些效应的拐点分别为 8.565、108.400、18.056 和 1.071。亚组分析表明,大多数亚组的相关性保持一致。利用 LASSO 回归确定的关键特征建立的提名图模型显示出出色的判别能力,曲线下面积值为 0.725:研究表明,METS-VF、WC、LAP 和 VAI 的增加与胆结石患病率的增加有关。利用 LASSO 回归法确定关键参数设计的提名图模型与胆结石的存在有密切联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between visceral lipid accumulation indicators and gallstones: a cross-sectional study based on NHANES 2017-2020.

Background: Obesity is a major contributing factor to the formation of gallstones. As early identification typically results in improved outcomes, we explored the relationship between visceral lipid accumulation indicators and the occurrence of gallstones.

Methods: This cross-sectional study involved 3,224 adults. The researchers employed multivariable logistic regression, smoothed curve fitting (SCF), threshold effects analysis, and subgroup analysis to examine the relationship between metabolic scores for visceral fat (METS-VF), waist circumference (WC), lipid accumulation products (LAP), and visceral adiposity index (VAI) and gallstones. A Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis was used to identify key factors which were then used in the construction of a nomogram model. The diagnostic efficacy of this model in detecting gallstones was then determined using receiver operating characteristic curves.

Results: Visceral lipid accumulation indicators were strongly linked to the likelihood of having gallstones. Specific saturation effects for METS-VF, WC, LAP, and VAI and gallstones were determined using SCF. The inflection points for these effects were found to be 8.565, 108.400, 18.056, and 1.071, respectively. Subgroup analyses showed that associations remained consistent in most subgroups. The nomogram model, which was developed using critical features identified by LASSO regression, demonstrated excellent discriminatory ability, as indicated by an area under the curve value of 0.725.

Conclusions: Studies have shown that increases in METS-VF, WC, LAP, and VAI are linked to increased prevalences of gallstones. The nomogram model, designed with critical parameters identified using LASSO regression, exhibits a strong association with the presence of gallstones.

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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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