绵羊和山羊静脉注射和皮下注射奥美拉唑的药代动力学比较

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Firas Serih, Charbel Fadel, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Amnart Poapolathep, Mario Giorgi
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引用次数: 0

摘要

腹腔溃疡是畜牧业面临的一项挑战,会影响动物的健康、福利和生产率。奥美拉唑(OPZ)治疗这些溃疡的疗效已众所周知,但其在成年山羊和绵羊体内的药代动力学(PK)数据却很缺乏。本研究的目的是调查和对比 OPZ 在这些动物体内单次静脉注射(IV,1 毫克/千克)和皮下注射(SC,2 毫克/千克)后的 PK 值。在所有给药途径中,绵羊和山羊的暴露水平相似,AUC(0-∞)D无明显变化。两种动物的半衰期都很短(绵羊:0.20 小时;山羊:0.31 小时)。山羊静脉注射后的分布容积更大。清除迅速,山羊和绵羊的萃取比值都很高(分别为 43% 和 30%)。经皮下注射的 Cmax 和 Tmax 值在不同物种之间有相似之处。山羊和绵羊的生物利用度(约 80%)都很高,平均吸收时间(MAT)也相当。尽管某些 PK 参数存在差异,但绵羊和山羊的 OPZ 全身暴露量相似。皮下注射的高生物利用度表明这是一种方便的田间施药途径。要了解 OPZ 对患有腹腔溃疡的小反刍动物的疗效并改进临床用药剂量,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Pharmacokinetics of Intravenous and Subcutaneous Omeprazole in Sheep and Goats.

Abomasal ulcers are a challenge in animal farming, affecting health, welfare, and productivity. Omeprazole's (OPZ) efficacy in treating these ulcers is known, but data on its pharmacokinetics (PK) in adult goats and sheep are lacking. The purpose of this research was to investigate and contrast OPZ's PK in these animals following a single intravenous (IV, 1 mg/kg) and subcutaneous (SC, 2 mg/kg) doses. Sheep and goats had similar exposure levels for all administration routes, with no significant AUC(0-∞)D variations. Half-life was short in both species (sheep: 0.20 h; goats: 0.31 h). Goats had a higher volume of distribution after IV administration. Clearance was rapid, and extraction ratio values were high for both goats and sheep (43% and 30%, respectively). SC administration showed similarities in Cmax and Tmax values between species. Both goats and sheep had high bioavailability (about 80%) levels and comparable mean absorption times (MAT). Despite some PK parameters' variances, systemic exposure to OPZ is similar in sheep and goats. SC administration's high bioavailability suggests it as a convenient field application route. Further investigations are needed to understand OPZ's effectiveness in small ruminants with abomasal ulcers and improve dosing regimens for clinical use.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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