学龄前自闭症谱系障碍右半球微结构异常。

IF 3.7 2区 医学 Q1 PSYCHIATRY
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引用次数: 0

摘要

背景:本研究旨在利用弥散基谱成像(DBSI)技术研究自闭症谱系障碍(ASD)学龄前儿童大脑半球内部和半球之间的微结构异常:本研究旨在利用弥散基谱成像(DBSI)研究学龄前自闭症谱系障碍(ASD)儿童大脑半球内部和半球之间的微结构异常:共有 35 名 ASD 患者和 32 名健康对照者(HC)在 3T 下接受了 DBSI。我们使用基于束的空间统计(TBSS)分析了DBSI衍生的脑白质指数,以比较ASD组和HC组。我们采用支持向量机(SVM)分类来评估 DBSI 阳性参数在区分 ASD 患者方面的潜力。此外,研究人员还进行了相关分析,以探讨DBSI阳性参数与临床量表之间的关系:结果:与HC相比,ASD组患者右侧脑干束的纤维比率明显升高,左侧上纵筋束的径向扩散率升高,投射、汇合和联结纤维等各种纤维束的分数各向异性(FA)降低。值得注意的是,右侧扣带回的FA与格塞尔量表呈正相关(r = 0.439,p = 0.008),在识别ASD方面的特异性达到90%:DBSI的研究结果表明,学龄前ASD患者右半球和小脑的髓鞘化不同步,右扣带回的FA值似乎是ASD的可靠标记,可作为学龄前ASD的潜在诊断参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microstructural abnormalities of the right hemisphere in preschool autism spectrum disorders

Background

This study aims to investigate microstructural abnormalities within and between hemispheres in preschool children with autism spectrum disorders (ASD) using diffusion basis spectrum imaging (DBSI).

Methods

A total of 35 ASD patients and 32 healthy controls (HC), matched for sex and age, underwent DBSI at 3T. We analyzed DBSI-derived indices of brain white matter using tract-based spatial statistics (TBSS) to compare ASD and HC groups. Support vector machine (SVM) classification was employed to evaluate the potential of positive DBSI parameters in distinguishing ASD patients. Additionally, correlation analyses were conducted to explore relationships between positive DBSI parameters and clinical scales.

Results

Patients in the ASD group exhibited significantly higher fiber ratios in the right brainstem tracts, increased radial diffusivity in the left superior longitudinal fasciculus, and reduced fractional anisotropy (FA) in various fiber tracts, including projection, commissural, and association fibers, compared to HC. Notably, the FA of the right cingulum correlated positively with the Gesell scale (r = 0.439, p = 0.008) and achieved a specificity of 90% in identifying ASD.

Conclusion

The DBSI findings suggest asynchronous myelination in the right hemisphere and cerebellum in preschool ASD, with the FA value of the right cingulate gyrus appearing to be a reliable marker for ASD and may serve as a potential diagnostic parameter for preschool ASD.
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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