作为前列腺恶性肿瘤表型潜在指标的动态可溶性 IL-6R/Soluble gp130 比率--一项多中心病例对照研究。

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Cosmin-Victor Ene, Bogdan Geavlete, Cristian Mares, Ilinca Nicolae, Corina Daniela Ene
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引用次数: 0

摘要

目的:前列腺肿瘤,无论是前列腺癌还是腺瘤,都是一项重大的公共卫生挑战。炎症研究的进展揭示了炎症、免疫和癌症之间的联系。在此背景下,本研究旨在发现炎症性肿瘤微环境中的 IL-6 信号系统异常:本研究为病例对照、多中心研究,共纳入 86 例患者,其中 43 例确诊为良性前列腺增生症,43 例确诊为 PCa,研究时间为 2019 年 1 月至 2020 年 1 月。研究组为同质研究,研究参数为IL-6复合物(IL-6、可溶性受体IL-6R、可溶性糖蛋白gp130)、急性期蛋白(C反应蛋白-CRP、酸性α1糖蛋白-AGPA、铁蛋白、白蛋白、转铁蛋白)和氧化应激相关变量(丙二醛-MDA、羰基化蛋白-PCO、8-羟基脱氧鸟苷-8-OHdG、总抗氧化状态-bTAS):炎症微环境决定了IL-6信号的改变(与良性前列腺增生症相比,PCa中sIL-6R的过度调节和sgp130的抑制)、急性期反应标志物的变化(血清中CRP、AGPA、铁蛋白水平升高,血清中白蛋白、转铁蛋白水平降低),与良性前列腺增生症相比,PCa中这些变化更为明显、大分子氧化损伤(MDA、PCO、8-OHdG)和内源性抗氧化剂(TAS)之间的不平衡,与良性前列腺增生症相比,在 PCa 中更为突出;sIL-6R/sgp130 比值与炎症/氧化应激相关因素之间的关联仅在 PCa 患者中具有代表性。结论:我们的研究再次证实了 IL-6 促进前列腺肿瘤发生的前人观点。在这项研究中,我们首次证明了高 sIL-6R/sgp130 比值有助于前列腺恶性肿瘤的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamic Soluble IL-6R/Soluble gp130 Ratio as a Potential Indicator for the Prostate Malignancy Phenotype-A Multicenter Case-Control Study.

Objective: Prostate tumors, if prostate cancer or adenoma, represent a major public health challenge. Progress in research on inflammation has revealed a connection between inflammation, immunity, and cancer. In this context, this study aimed to find IL-6 signaling systemic abnormalities in the inflammatory tumor microenvironment.

Material and methods: This study was case-controlled, multicentered, and included 86 patients, 43 diagnosed with BPH and 43 diagnosed with PCa, between January 2019 and January 2020. The study group was homogenous and the studied parameters were IL-6 complex (IL-6, soluble receptor IL-6R, soluble glycoprotein gp130), acute phase proteins (C reactive protein-CRP, acid alpha1 glycoprotein-AGPA, ferritin, albumin, transferrin), and oxidative stress-associated variables (malondialdehyde-MDA, carbonylated protein-PCO, 8-hydroxy-deoxy guanosine-8-OHdG, total antioxidant status-bTAS).

Results: The inflammatory microenvironment determined IL-6 signaling alterations (over-regulation of sIL-6R and suppression of sgp130 in PCa versus BPH), changes in acute phase reaction markers (increased serum levels of CRP, AGPA, ferritin, and decreased serum levels of albumin, transferrin) that were much more evident in PCa compared to BPH, an imbalance between macromolecular oxidative damage (MDA, PCO, 8-OHdG) and endogenous antioxidants (TAS) that was more accentuated in PCa compared with BPH, and a representative association between the sIL-6R/sgp130 ratio and inflammatory/oxidative stress-related factors only in PCa patients.

Conclusions: Our study reconfirms the anterior concept that IL-6 promotes prostatic tumorigenesis. In this study, we first demonstrated that a high sIL-6R/sgp130 ratio facilitates prostate malignancy.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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