髓鞘少突胶质细胞糖蛋白抗体相关疾病，组织病理学特征为无脱髓鞘的原发性中枢神经系统血管炎：病例报告和文献综述。

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-10-18 DOI:10.1016/j.jneuroim.2024.578467

Seongmi Kim , Suin Lee , Yeon Hak Chung , Hyunjin Ju , Yeon-Lim Suh , Ju-Hong Min

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引用次数: 0

摘要

原发性中枢神经系统血管炎（PACNS）是一种影响中枢神经系统中小血管的罕见炎症性疾病，而髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）是一种新型抗体介导的炎症性脱髓鞘疾病，会导致中枢神经系统髓鞘受损。我们报告了一例因反复脊髓炎病史、脑部病变和抗 MOG 阳性而被诊断为 MOGAD 的病例，但脑活检显示为血管炎而无脱髓鞘。

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Myelin oligodendrocyte glycoprotein antibody–associated disease with histopathologic features of primary CNS angiitis without demyelination: Case report and literature review

Primary angiitis of the central nervous system (PACNS) is a rare inflammatory disease that affects both small- and medium-sized vessels of the CNS, while myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) is a novel antibody-mediated inflammatory demyelinating disorder that causes damage to the myelin in CNS. We report a case diagnosed as MOGAD due to a history of recurrent myelitis, brain lesions, and positive anti-MOG, but the brain biopsy showed vasculitis without demyelination.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.