Karin Odoj, Jacopo Garlasco, Maria Diletta Pezzani, Cristina Magnabosco, Diego Ortiz, Federica Manco, Liliana Galia, Sarah K Foster, Fabiana Arieti, Evelina Tacconelli
{"title":"追踪整个欧洲的念珠菌病趋势和抗真菌耐药性模式：对监测系统和监测研究的深入分析。","authors":"Karin Odoj, Jacopo Garlasco, Maria Diletta Pezzani, Cristina Magnabosco, Diego Ortiz, Federica Manco, Liliana Galia, Sarah K Foster, Fabiana Arieti, Evelina Tacconelli","doi":"10.3390/jof10100685","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The WHO fungal priority list classifies <i>Candida</i> species as critical and high-priority pathogens, and the WHO GLASS fungi initiative seeks to establish a standardised global framework for antifungal resistance monitoring. We aimed to review resistance rates and antifungal resistance patterns across European surveillance systems and studies in response to these recent calls for action.</p><p><strong>Methods: </strong>A systematic review of national and international surveillance systems and peer-reviewed surveillance studies available up to June 2024 was conducted. Descriptive and trend analyses were performed on surveillance data reporting resistance to different antifungals in <i>Candida</i> spp.</p><p><strong>Results: </strong>In total, 6 national surveillance systems and 28 studies from 13 countries provided candidemia resistance data, mostly about the <i>C. albicans</i>, <i>C. glabrata</i> and <i>C. parapsilosis</i> complex. Azole resistance was most frequently reported (6/6 surveillance systems and 27/28 studies) with the highest resistance rate, especially for <i>C. glabrata</i>, in Croatia (100%, 28/28 isolates) and Slovenia (85.7%, 82/96) and <i>C. parapsilosis</i> in Croatia (80.6%, 54/67) and Italy (72.6%, 106/146). Echinocandin and polyene resistance rates were nearly zero. The number of isolates included in the surveillance systems increased over the years, particularly for <i>C. albicans</i> (+40-60 isolates/year), <i>C. glabrata</i>, and <i>C. parapsilosis</i> (+15-30 isolates/year). No surveillance system or study reported resistance data for <i>C. auris</i>. Pooled data from national surveillance revealed a decreasing trend in azole resistance in <i>C. albicans</i> and <i>C. glabrata</i>. The increasing azole-resistance trend in <i>C. parapsilosis</i> disappeared after adjusting for between-country heterogeneity. Overall, echinocandin and polyene resistance trends appeared relatively stable.</p><p><strong>Conclusions: </strong>Awareness of antifungal resistance is growing, but further actions are needed to strengthen surveillance capacity and knowledge-sharing networks across Europe.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 10","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514733/pdf/","citationCount":"0","resultStr":"{\"title\":\"Tracking Candidemia Trends and Antifungal Resistance Patterns across Europe: An In-Depth Analysis of Surveillance Systems and Surveillance Studies.\",\"authors\":\"Karin Odoj, Jacopo Garlasco, Maria Diletta Pezzani, Cristina Magnabosco, Diego Ortiz, Federica Manco, Liliana Galia, Sarah K Foster, Fabiana Arieti, Evelina Tacconelli\",\"doi\":\"10.3390/jof10100685\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The WHO fungal priority list classifies <i>Candida</i> species as critical and high-priority pathogens, and the WHO GLASS fungi initiative seeks to establish a standardised global framework for antifungal resistance monitoring. We aimed to review resistance rates and antifungal resistance patterns across European surveillance systems and studies in response to these recent calls for action.</p><p><strong>Methods: </strong>A systematic review of national and international surveillance systems and peer-reviewed surveillance studies available up to June 2024 was conducted. Descriptive and trend analyses were performed on surveillance data reporting resistance to different antifungals in <i>Candida</i> spp.</p><p><strong>Results: </strong>In total, 6 national surveillance systems and 28 studies from 13 countries provided candidemia resistance data, mostly about the <i>C. albicans</i>, <i>C. glabrata</i> and <i>C. parapsilosis</i> complex. Azole resistance was most frequently reported (6/6 surveillance systems and 27/28 studies) with the highest resistance rate, especially for <i>C. glabrata</i>, in Croatia (100%, 28/28 isolates) and Slovenia (85.7%, 82/96) and <i>C. parapsilosis</i> in Croatia (80.6%, 54/67) and Italy (72.6%, 106/146). Echinocandin and polyene resistance rates were nearly zero. The number of isolates included in the surveillance systems increased over the years, particularly for <i>C. albicans</i> (+40-60 isolates/year), <i>C. glabrata</i>, and <i>C. parapsilosis</i> (+15-30 isolates/year). No surveillance system or study reported resistance data for <i>C. auris</i>. Pooled data from national surveillance revealed a decreasing trend in azole resistance in <i>C. albicans</i> and <i>C. glabrata</i>. The increasing azole-resistance trend in <i>C. parapsilosis</i> disappeared after adjusting for between-country heterogeneity. Overall, echinocandin and polyene resistance trends appeared relatively stable.</p><p><strong>Conclusions: </strong>Awareness of antifungal resistance is growing, but further actions are needed to strengthen surveillance capacity and knowledge-sharing networks across Europe.</p>\",\"PeriodicalId\":15878,\"journal\":{\"name\":\"Journal of Fungi\",\"volume\":\"10 10\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514733/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Fungi\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3390/jof10100685\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fungi","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/jof10100685","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Tracking Candidemia Trends and Antifungal Resistance Patterns across Europe: An In-Depth Analysis of Surveillance Systems and Surveillance Studies.
Background: The WHO fungal priority list classifies Candida species as critical and high-priority pathogens, and the WHO GLASS fungi initiative seeks to establish a standardised global framework for antifungal resistance monitoring. We aimed to review resistance rates and antifungal resistance patterns across European surveillance systems and studies in response to these recent calls for action.
Methods: A systematic review of national and international surveillance systems and peer-reviewed surveillance studies available up to June 2024 was conducted. Descriptive and trend analyses were performed on surveillance data reporting resistance to different antifungals in Candida spp.
Results: In total, 6 national surveillance systems and 28 studies from 13 countries provided candidemia resistance data, mostly about the C. albicans, C. glabrata and C. parapsilosis complex. Azole resistance was most frequently reported (6/6 surveillance systems and 27/28 studies) with the highest resistance rate, especially for C. glabrata, in Croatia (100%, 28/28 isolates) and Slovenia (85.7%, 82/96) and C. parapsilosis in Croatia (80.6%, 54/67) and Italy (72.6%, 106/146). Echinocandin and polyene resistance rates were nearly zero. The number of isolates included in the surveillance systems increased over the years, particularly for C. albicans (+40-60 isolates/year), C. glabrata, and C. parapsilosis (+15-30 isolates/year). No surveillance system or study reported resistance data for C. auris. Pooled data from national surveillance revealed a decreasing trend in azole resistance in C. albicans and C. glabrata. The increasing azole-resistance trend in C. parapsilosis disappeared after adjusting for between-country heterogeneity. Overall, echinocandin and polyene resistance trends appeared relatively stable.
Conclusions: Awareness of antifungal resistance is growing, but further actions are needed to strengthen surveillance capacity and knowledge-sharing networks across Europe.
期刊介绍：
Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.
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