将氨甲酰化血红蛋白作为区分急性肾损伤和慢性肾病的替代标志物的临床比较研究。

IF 1.1 Q4 PRIMARY HEALTH CARE
H K Keshava, Sana Sultana, G C Suhas, H R Chadrashekhar
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引用次数: 0

摘要

简介氨甲酰化血红蛋白是异氰酸酯与血红蛋白α和β链N端缬氨酸残基反应的结果。氨甲酰化血红蛋白的浓度取决于尿毒症的程度和持续时间,因此有可能成为区分急性肾损伤(AKI)和慢性肾病(CKD)的标志物:方法:在一家城市三级医疗中心开展了一项基于医院的前瞻性临床比较研究。共对 60 名患者(慢性肾病和急性肾损伤患者各 30 名)的氨甲酰化血红蛋白进行了估计。氨甲酰化血红蛋白水平在慢性肾脏病组和急性肾损伤组之间的比较采用 Mann-Whitney 检验法。在 CKD 组中,氨甲酰化血红蛋白的平均值为 240.71 ± 75.64 μgVH/g,而在 AKI 组中,氨甲酰化血红蛋白的平均值为 67.15 ± 17.05 μgVH/g。这些数值具有统计学意义(P < 0.001):结果:氨甲酰化血红蛋白值升高与肾功能不全有关,并且与肾病的慢性化程度显著相关。与 AKI 组相比,CKD 组的平均 CarHb 明显偏高,且具有统计学意义,P 值为 结论:本研究结果表明,氨甲酰化血红蛋白 >100 μgVH/g 可诊断为 CKD,其值越高,CKD 的诊断率越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A clinical comparative study on carbamylated haemoglobin as a surrogate marker to differentiate acute kidney injury from chronic kidney disease.

Introduction: Carbamylated haemoglobin is the result of reaction of isocyanate with N-terminal valine residues of the α and β chains of haemoglobin. Carbamylated haemoglobin concentration is dependent on the degree and duration of uraemia and thus may potentially serve as a marker to differentiate acute kidney injury (AKI) and chronic kidney disease (CKD).

Methods: A hospital-based prospective clinical comparative study was conducted in an urban tertiary medical care centre. Carbamylated haemoglobin was estimated in a total of 60 patients, 30 each of chronic kidney disease and acute kidney injury. The comparison of the carbamylated haemoglobin levels among the CKD and AKI groups was done using Mann-Whitney test. The mean value of carbamylated haemoglobin among the CKD group was 240.71 ± 75.64 μgVH/g, whereas among the AKI group, it was 67.15 ± 17.05 μgVH/g. These values are statistically significant with P < 0.001.

Results: Carbamylated haemoglobin values were elevated in relation to renal dysfunction, and it significantly correlated with chronicity of kidney disease. Mean CarHb among the CKD group was significantly high in comparison to the AKI group with statistical significance, with a P value of <0.001.

Conclusion: It was significantly attributed in this study that carbamylated haemoglobin >100 μgVH/g is diagnostic of CKD and a value <100 μgVH/g is diagnostic of AKI. Thus, in this study, it can be concluded that carbamylated haemoglobin is a useful marker to differentiate AKI from CKD.

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