由 Bartonella vinsonii subsp. berkhoffii 引起的人工瓣膜人类心内膜炎。

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Iñaki Beguiristain , Aitziber Aguinaga , Miguel Fernandez-Huerta , Rafael Sadaba , Carmen Ezpeleta
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引用次数: 0

摘要

巴顿氏菌感染越来越被认为是人畜共患疾病的病因。巴顿氏菌引起的最严重感染之一是感染性心内膜炎,主要影响患有潜在瓣膜性心脏病、免疫抑制和无家可归的人。这些心内膜炎病例的微生物学诊断极具挑战性,因为巴顿氏菌具有快速繁殖的特性,除了通常呈阴性的血液培养外,还需要进行专门的血清学和分子检测。虽然鸡毒杆菌和五联鸡毒杆菌是与此类感染相关的主要菌种,但在此类病例中也越来越多地发现了其他罕见的巴顿氏菌菌种。在此,我们报告了首例由巴顿氏菌 vinsonii 亚种 berkhofii 引起的人工心脏瓣膜感染性心内膜炎病例,患者是一名 74 岁的牧羊人,这也是报告的第四例由该病原体引起的人类心内膜炎病例。这种巴顿氏菌亚种与接触犬科动物有关,因为这些动物被认为是其主要的贮藏库。有趣的是,在我们的病例中,细菌在心脏瓣膜培养液中生长,因此可以通过全基因组测序鉴定其种类。我们这位患者的风险因素包括接触犬科动物、心脏异常和免疫抑制,这充分说明了在此类高危人群中考虑这种病原体的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human endocarditis on prosthetic valves due to Bartonella vinsonii subsp. berkhoffii
Bartonella spp. infections are increasingly recognized as causes of zoonotic diseases. One of the most severe infections caused by Bartonella spp. is infective endocarditis, predominantly affecting individuals with underlying valvular heart disease, immunosuppression, and homelessness. The microbiological diagnosis of these endocarditis cases is highly challenging due to the fastidious nature of Bartonella spp., requiring specialized serologic and molecular tests in addition to blood cultures, which are usually negative. While Bartonella henselae and Bartonella quintana are the main species associated with these infections, other rarer Bartonella species are increasingly being identified in such cases. Herein, we report the first case of infective endocarditis on prosthetic heart valves caused by Bartonella vinsonii subsp. berkhoffii in a 74-year-old shepherd, also being the fourth reported human endocarditis case due to this pathogen. This Bartonella subspecies has been associated with canid exposure, as these animals are believed to be its main reservoir. Interestingly, in our case the bacteria grew in heart-valve culture, allowing for species identification by whole-genome sequencing. Our patient, whose risk factors included canid exposure, cardiac anomalies, and immunosuppression, is a clear example of the importance of considering this pathogen in such high-risk populations.
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来源期刊
CiteScore
18.90
自引率
2.40%
发文量
1020
审稿时长
30 days
期刊介绍: International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.
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