2019-2022年台湾男男性行为者中无症状肠道病原体携带及其与使用质子泵抑制剂的关系。

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-10-22 DOI:10.1016/j.ijid.2024.107273

Chin-Shiang Tsai , Nan-Yao Lee , Po-Lin Chen , Szu-Ying Chen , Ying-Jun Lin , Pei-Fang Tsai , Huey-Pin Tsai , Jiun-Ling Wang , Wen-Chien Ko

{"title":"2019-2022年台湾男男性行为者中无症状肠道病原体携带及其与使用质子泵抑制剂的关系。","authors":"Chin-Shiang Tsai , Nan-Yao Lee , Po-Lin Chen , Szu-Ying Chen , Ying-Jun Lin , Pei-Fang Tsai , Huey-Pin Tsai , Jiun-Ling Wang , Wen-Chien Ko","doi":"10.1016/j.ijid.2024.107273","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Currently recognized risk factors for sexually transmitted enteric infections (STEIs) among men who have sex with men (MSM) include oroanal sex, multiple sexual partners, and chemsex. This study aimed to investigate the prevalence of the asymptomatic carriage of enteric pathogens in men who have sex with men (MSM) and to identify the associated risk factors.</div></div><div><h3>Methods</h3><div>Questionnaires were completed by 375 MSM in Taiwan from December 2019 to November 2022. Fecal samples were analyzed by multiplex PCR to determine whether seven enteric pathogens, including <em>Entamoeba histolytica, Giardia duodenalis</em>, Shiga toxin-producing <em>Escherichia coli, Cryptosporidium, Campylobacter, Salmonella</em>, and <em>Shigella</em> species, were present.</div></div><div><h3>Results</h3><div>Among 375 fecal samples from asymptomatic MSM, 27 (7.2%) fecal samples tested positive for at least one enteric pathogen. The recent use of proton pump inhibitors (PPIs) was significantly associated with asymptomatic fecal carriage (22.2% <em>vs.</em> 2.0%, <em>P</em> < 0.001). <em>G. duodenalis</em> (2.1%, 8 cases), <em>E. histolytica</em> (1.6%, 6 cases), and <em>Shigella</em> species (1.3%, 5 cases) were commonly detected. Oroanal sex and PPI use were associated with the asymptomatic carriage of enteric pathogens. Specifically, <em>Shigella, Salmonella</em>, or <em>Campylobacter</em> carriage was significantly correlated with PPI use. In contrast, rectal gonorrhea was associated with multiple sexual partners and prior syphilis.</div></div><div><h3>Conclusions</h3><div>Recent use of PPIs was associated with the asymptomatic carriage of enteric pathogens. Therefore, targeted education about the appropriate use of PPIs is necessary to mitigate the risk of STEIs among MSM.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"149 ","pages":"Article 107273"},"PeriodicalIF":4.8000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Asymptomatic enteric pathogen carriage and its association with proton pump inhibitors use in men who have sex with men in Taiwan, 2019-2022\",\"authors\":\"Chin-Shiang Tsai , Nan-Yao Lee , Po-Lin Chen , Szu-Ying Chen , Ying-Jun Lin , Pei-Fang Tsai , Huey-Pin Tsai , Jiun-Ling Wang , Wen-Chien Ko\",\"doi\":\"10.1016/j.ijid.2024.107273\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Currently recognized risk factors for sexually transmitted enteric infections (STEIs) among men who have sex with men (MSM) include oroanal sex, multiple sexual partners, and chemsex. This study aimed to investigate the prevalence of the asymptomatic carriage of enteric pathogens in men who have sex with men (MSM) and to identify the associated risk factors.</div></div><div><h3>Methods</h3><div>Questionnaires were completed by 375 MSM in Taiwan from December 2019 to November 2022. Fecal samples were analyzed by multiplex PCR to determine whether seven enteric pathogens, including <em>Entamoeba histolytica, Giardia duodenalis</em>, Shiga toxin-producing <em>Escherichia coli, Cryptosporidium, Campylobacter, Salmonella</em>, and <em>Shigella</em> species, were present.</div></div><div><h3>Results</h3><div>Among 375 fecal samples from asymptomatic MSM, 27 (7.2%) fecal samples tested positive for at least one enteric pathogen. The recent use of proton pump inhibitors (PPIs) was significantly associated with asymptomatic fecal carriage (22.2% <em>vs.</em> 2.0%, <em>P</em> < 0.001). <em>G. duodenalis</em> (2.1%, 8 cases), <em>E. histolytica</em> (1.6%, 6 cases), and <em>Shigella</em> species (1.3%, 5 cases) were commonly detected. Oroanal sex and PPI use were associated with the asymptomatic carriage of enteric pathogens. Specifically, <em>Shigella, Salmonella</em>, or <em>Campylobacter</em> carriage was significantly correlated with PPI use. In contrast, rectal gonorrhea was associated with multiple sexual partners and prior syphilis.</div></div><div><h3>Conclusions</h3><div>Recent use of PPIs was associated with the asymptomatic carriage of enteric pathogens. Therefore, targeted education about the appropriate use of PPIs is necessary to mitigate the risk of STEIs among MSM.</div></div>\",\"PeriodicalId\":14006,\"journal\":{\"name\":\"International Journal of Infectious Diseases\",\"volume\":\"149 \",\"pages\":\"Article 107273\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1201971224003448\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1201971224003448","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

目的：目前在男男性行为者（MSM）中公认的性传播肠道感染（STEI）风险因素包括口交、多个性伴侣和化学性交。本研究旨在调查男男性行为者（MSM）中无症状肠道病原体携带率，并确定相关风险因素：方法：2019年12月至2022年11月，台湾375名男男性行为者填写了调查问卷。通过多重 PCR 分析粪便样本，确定是否存在七种肠道病原体，包括组织溶解恩塔米巴虫、十二指肠贾第虫、产志贺毒素大肠杆菌、隐孢子虫、弯曲杆菌、沙门氏菌和志贺氏杆菌：在无症状 MSM 的 375 份粪便样本中，有 27 份（7.2%）粪便样本检测出至少一种肠道病原体呈阳性。近期使用质子泵抑制剂（PPIs）与无症状粪便携带率明显相关（22.2% vs. 2.0%，P < 0.001）。常见的粪便携带菌有十二指肠球菌（2.1%，8 例）、组织溶解性大肠杆菌（1.6%，6 例）和志贺氏菌（1.3%，5 例）。口腔性别和使用 PPI 与无症状携带肠道病原体有关。具体来说，志贺氏菌、沙门氏菌或弯曲杆菌的携带与使用 PPI 显著相关。相比之下，直肠淋病与多个性伴侣和既往梅毒有关：结论：近期使用 PPIs 与无症状携带肠道病原体有关。因此，有必要就如何正确使用 PPIs 开展有针对性的教育，以降低 MSM 感染 STEIs 的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Asymptomatic enteric pathogen carriage and its association with proton pump inhibitors use in men who have sex with men in Taiwan, 2019-2022

查看原文本刊更多论文

Asymptomatic enteric pathogen carriage and its association with proton pump inhibitors use in men who have sex with men in Taiwan, 2019-2022

Objectives

Currently recognized risk factors for sexually transmitted enteric infections (STEIs) among men who have sex with men (MSM) include oroanal sex, multiple sexual partners, and chemsex. This study aimed to investigate the prevalence of the asymptomatic carriage of enteric pathogens in men who have sex with men (MSM) and to identify the associated risk factors.

Methods

Questionnaires were completed by 375 MSM in Taiwan from December 2019 to November 2022. Fecal samples were analyzed by multiplex PCR to determine whether seven enteric pathogens, including Entamoeba histolytica, Giardia duodenalis, Shiga toxin-producing Escherichia coli, Cryptosporidium, Campylobacter, Salmonella, and Shigella species, were present.

Results

Among 375 fecal samples from asymptomatic MSM, 27 (7.2%) fecal samples tested positive for at least one enteric pathogen. The recent use of proton pump inhibitors (PPIs) was significantly associated with asymptomatic fecal carriage (22.2% vs. 2.0%, P < 0.001). G. duodenalis (2.1%, 8 cases), E. histolytica (1.6%, 6 cases), and Shigella species (1.3%, 5 cases) were commonly detected. Oroanal sex and PPI use were associated with the asymptomatic carriage of enteric pathogens. Specifically, Shigella, Salmonella, or Campylobacter carriage was significantly correlated with PPI use. In contrast, rectal gonorrhea was associated with multiple sexual partners and prior syphilis.

Conclusions

Recent use of PPIs was associated with the asymptomatic carriage of enteric pathogens. Therefore, targeted education about the appropriate use of PPIs is necessary to mitigate the risk of STEIs among MSM.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.