Figen Batıoğlu, Özge Yanık, Pınar Aydın Ellialtıoğlu, Sibel Demirel, Esra Şahlı, Emin Özmert
{"title":"与斯塔加特病相关的中心性黄斑萎缩和非渗出性老年性黄斑变性眼脉络膜结构特征的比较研究。","authors":"Figen Batıoğlu, Özge Yanık, Pınar Aydın Ellialtıoğlu, Sibel Demirel, Esra Şahlı, Emin Özmert","doi":"10.4103/IJO.IJO_1005_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To compare choroidal structural features in eyes with central macular atrophy related to Stargardt disease (STGD) and non-exudative age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>Twenty-five eyes of 25 Stargardt cases and 25 eyes of 25 non-exudative AMD cases were included in this retrospective study. Region Finder software was used to measure atrophic areas on blue-light fundus autofluorescence images centered on the macula. The total choroidal area (TCA), luminal area (LA), and stromal area (SA) were calculated using the ImageJ program and Niblack autolocal thresholding method. The choroidal vascularity index (CVI) was assessed.</p><p><strong>Results: </strong>The mean age was 59.4 ± 10.9 years in the STGD group and 68.1 ± 7.6 years in the non-exudative AMD group (P = 0.002). The mean macular atrophic area was 16.06 ± 10.61 mm2 in STGD and 11.73 ± 7.65 mm2 in non-exudative AMD (P = 0.171). The STGD group had significantly higher mean subfoveal choroidal thickness (184.0 ± 62.6 vs. 131.8 ± 62.4 µm), TCA (0.553 ± 0.201 vs. 0.406 ± 0.189 mm2), LA (0.344 ± 0.150 vs. 0.253 ± 0.124 mm2), and SA values (0.208 ± 0.062 vs. 0.153 ± 0.069 mm2) compared to the non-exudative AMD group (P = 0.004, P = 0.011, P = 0.023, and P = 0.004, respectively). However, CVI values did not differ significantly between the two groups (60.58 ± 7.4 vs. 61.93 ± 5.8%, P = 0.432). According to the results of the ANCOVA test, differences in mean SFCT, TCA, and SA persisted when the data were readjusted for age (P = 0.018, P = 0.035, and P = 0.017, respectively).</p><p><strong>Conclusion: </strong>In non-exudative AMD with geographic atrophy, the reductions in the choroidal compartments are more pronounced than those in STGD. However, similar CVI values may suggest that controversy still exists regarding the role of choroidal compartmental changes in the development of atrophy.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"72 Suppl 5","pages":"S887-S892"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A comparative study of choroidal structural features in eyes with central macular atrophy related to Stargardt disease and non-exudative age-related macular degeneration.\",\"authors\":\"Figen Batıoğlu, Özge Yanık, Pınar Aydın Ellialtıoğlu, Sibel Demirel, Esra Şahlı, Emin Özmert\",\"doi\":\"10.4103/IJO.IJO_1005_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To compare choroidal structural features in eyes with central macular atrophy related to Stargardt disease (STGD) and non-exudative age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>Twenty-five eyes of 25 Stargardt cases and 25 eyes of 25 non-exudative AMD cases were included in this retrospective study. Region Finder software was used to measure atrophic areas on blue-light fundus autofluorescence images centered on the macula. The total choroidal area (TCA), luminal area (LA), and stromal area (SA) were calculated using the ImageJ program and Niblack autolocal thresholding method. The choroidal vascularity index (CVI) was assessed.</p><p><strong>Results: </strong>The mean age was 59.4 ± 10.9 years in the STGD group and 68.1 ± 7.6 years in the non-exudative AMD group (P = 0.002). The mean macular atrophic area was 16.06 ± 10.61 mm2 in STGD and 11.73 ± 7.65 mm2 in non-exudative AMD (P = 0.171). The STGD group had significantly higher mean subfoveal choroidal thickness (184.0 ± 62.6 vs. 131.8 ± 62.4 µm), TCA (0.553 ± 0.201 vs. 0.406 ± 0.189 mm2), LA (0.344 ± 0.150 vs. 0.253 ± 0.124 mm2), and SA values (0.208 ± 0.062 vs. 0.153 ± 0.069 mm2) compared to the non-exudative AMD group (P = 0.004, P = 0.011, P = 0.023, and P = 0.004, respectively). However, CVI values did not differ significantly between the two groups (60.58 ± 7.4 vs. 61.93 ± 5.8%, P = 0.432). According to the results of the ANCOVA test, differences in mean SFCT, TCA, and SA persisted when the data were readjusted for age (P = 0.018, P = 0.035, and P = 0.017, respectively).</p><p><strong>Conclusion: </strong>In non-exudative AMD with geographic atrophy, the reductions in the choroidal compartments are more pronounced than those in STGD. However, similar CVI values may suggest that controversy still exists regarding the role of choroidal compartmental changes in the development of atrophy.</p>\",\"PeriodicalId\":13329,\"journal\":{\"name\":\"Indian Journal of Ophthalmology\",\"volume\":\"72 Suppl 5\",\"pages\":\"S887-S892\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/IJO.IJO_1005_24\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/IJO.IJO_1005_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:比较Stargardt病(STGD)和非渗出性年龄相关性黄斑变性(AMD)中心性黄斑萎缩患者的脉络膜结构特征:这项回顾性研究纳入了25例Stargardt病例中的25只眼睛和25例非渗出性AMD病例中的25只眼睛。使用区域查找器软件测量以黄斑为中心的蓝光眼底自动荧光图像上的萎缩区域。使用 ImageJ 程序和 Niblack 自动局部阈值法计算脉络膜总面积(TCA)、管腔面积(LA)和基质面积(SA)。评估了脉络膜血管指数(CVI):STGD组的平均年龄为(59.4 ± 10.9)岁,非渗出性AMD组的平均年龄为(68.1 ± 7.6)岁(P = 0.002)。STGD组的平均黄斑萎缩面积为(16.06 ± 10.61)平方毫米,非渗出性AMD组为(11.73 ± 7.65)平方毫米(P = 0.171)。STGD 组的平均视网膜下脉络膜厚度(184.0 ± 62.6 vs. 131.8 ± 62.4 µm)、TCA(0.553 ± 0.201 vs. 0.406 ± 0.189 mm2)、LA(0.344 ± 0.150 vs. 0.253 ± 0.124 mm2)均明显高于非渗出性 AMD 组。与非渗出性黄斑变性组相比(P = 0.004、P = 0.011、P = 0.023 和 P = 0.004),LA 值(0.253 ± 0.124 平方毫米)和 SA 值(0.208 ± 0.062 vs. 0.153 ± 0.069 平方毫米)的差异更大(P = 0.004、P = 0.011、P = 0.023 和 P = 0.004)。然而,两组的 CVI 值差异不大(60.58 ± 7.4 vs. 61.93 ± 5.8%,P = 0.432)。根据方差分析检验结果,当根据年龄重新调整数据时,平均 SFCT、TCA 和 SA 的差异仍然存在(分别为 P = 0.018、P = 0.035 和 P = 0.017):结论:在伴有地理萎缩的非渗出性 AMD 患者中,脉络膜区的减少比 STGD 患者更明显。然而,相似的 CVI 值可能表明,关于脉络膜区室变化在萎缩发展中的作用仍存在争议。
A comparative study of choroidal structural features in eyes with central macular atrophy related to Stargardt disease and non-exudative age-related macular degeneration.
Purpose: To compare choroidal structural features in eyes with central macular atrophy related to Stargardt disease (STGD) and non-exudative age-related macular degeneration (AMD).
Methods: Twenty-five eyes of 25 Stargardt cases and 25 eyes of 25 non-exudative AMD cases were included in this retrospective study. Region Finder software was used to measure atrophic areas on blue-light fundus autofluorescence images centered on the macula. The total choroidal area (TCA), luminal area (LA), and stromal area (SA) were calculated using the ImageJ program and Niblack autolocal thresholding method. The choroidal vascularity index (CVI) was assessed.
Results: The mean age was 59.4 ± 10.9 years in the STGD group and 68.1 ± 7.6 years in the non-exudative AMD group (P = 0.002). The mean macular atrophic area was 16.06 ± 10.61 mm2 in STGD and 11.73 ± 7.65 mm2 in non-exudative AMD (P = 0.171). The STGD group had significantly higher mean subfoveal choroidal thickness (184.0 ± 62.6 vs. 131.8 ± 62.4 µm), TCA (0.553 ± 0.201 vs. 0.406 ± 0.189 mm2), LA (0.344 ± 0.150 vs. 0.253 ± 0.124 mm2), and SA values (0.208 ± 0.062 vs. 0.153 ± 0.069 mm2) compared to the non-exudative AMD group (P = 0.004, P = 0.011, P = 0.023, and P = 0.004, respectively). However, CVI values did not differ significantly between the two groups (60.58 ± 7.4 vs. 61.93 ± 5.8%, P = 0.432). According to the results of the ANCOVA test, differences in mean SFCT, TCA, and SA persisted when the data were readjusted for age (P = 0.018, P = 0.035, and P = 0.017, respectively).
Conclusion: In non-exudative AMD with geographic atrophy, the reductions in the choroidal compartments are more pronounced than those in STGD. However, similar CVI values may suggest that controversy still exists regarding the role of choroidal compartmental changes in the development of atrophy.
期刊介绍:
Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.