UNCONTROLLED TYPE 2 DIABETES MELLITUS MODULATED PLASMA LEVELS OF LIPID CATABOLIC PROTEINS.

Background and objectives: This research is considered the first of its kind in Kirkuk City to study the activity of lecithin cholesterol acyl transferase (LCAT), the levels of apolipoprotein A-1 (Apo A-1), and Fatty acid binding protein-4 (FABP4) and some biochemical variables in T2DM patients who uncontrolled the disease (glycated hemoglobin (HbA1C)˃8%) and compared with patients who controlled the disease (HbA1C˂7%) and healthy controls (HbA1C≤5.5%), and find the correlation among them.

Methods: This research included 184 persons [128 patients (70 uncontrolled DM and 58 controlled DM + 56 healthy patients] aged (40-80) years from both sexes. The current study is divided into three groups: uncontrolled DM patients (G1) and controlled DM patients (G2) are compared to healthy controls (G3). Activity of LCAT, concentration of Apo A1, FABP4, insulin, fasting serum glucose (FSG), lipid profile and HbAc1% were evaluated and -correlated.

Results: The study found a significant rise in in HbAc1(%), FSG, TG, Cholesterol, LDL, VLDL, and FABP4 levels in uncontrolled diabetic patients (G1) compared to controlled diabetes (G2) and healthy controls (G3). At the same time, there are no significant (P value =0.2) differences between controlled DM patients (G2) and controlled healthy groups (G3). The study found no significant differences in insulin level among DM patients (G1), controlled DM patients (G2), and healthy controls (G3) (P = 0.2) while the LCAT activity, the concentration of HDL and ApoA1showed significant decreased (P=0.01) among G1, G2, compared to G3.