Zelong Han, Qingyuan Li, Chanelle Yeh Chua, Zhenjiang Wang, Jun Zhong, Ying Huang, Shaohui Huang, Aimin Li, Side Liu, Xiaobei Luo
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引用次数: 0
摘要
背景和目的:内镜黏膜下剥离术(ESD)通常用于治疗上皮性胃肠道肿瘤,但很少有研究探讨ESD用于治疗十二指肠乳头状腺瘤(PA)。在本研究中,我们旨在评估改良ESD方法作为切除PA的替代方式的可行性。方法:我们通过回顾性分析 10 例通过ESD切除的十二指肠乳头状腺瘤,与通过内镜乳头切除术(EP)切除的配对病变进行比较,评估了改良ESD切除散发性十二指肠乳头状腺瘤的潜在优势。结果:所有接受ESD切除的病灶均全切,切缘阴性,而接受EP切除的病灶中,60%的病灶切缘阴性。在实验组中,出血和胰腺炎病例各一例,而对照组有四例出血和一例胰腺炎。ESD组在平均 11.2 个月的随访时间内未发现复发,而对照组在平均 27.7 个月的随访时间内发现了三例复发。结论:从我们的初步经验来看,ESD 是治疗浅表十二指肠 PA 的一种很有前途的替代方法;但是,还需要进一步的研究。
Modified Endoscopic Submucosal Dissection-An Alternative Modality for the Treatment of Sporadic Duodenal Papillary Adenomas.
Background and Aim: Endoscopic submucosal dissection (ESD) is commonly employed in the treatment of epithelial gastrointestinal tumors, but few studies have explored ESD for treatment of duodenal papillary adenomas (PAs). In this study, we aim to evaluate the feasibility of a modified ESD method as an alternative modality in the resection of PAs. Methods: We evaluated potential advantages of modified ESD for resection of sporadic duodenal PAs through retrospective analysis of 10 PAs resected via ESD compared to paired lesions undergoing endoscopic papillectomy (EP). Results: All lesions undergoing ESD were resected en bloc with negative margins, compared to 60% of lesions undergoing EP. Within the experimental group, there was one case each of melena and pancreatitis compared to four bleeds and one case of pancreatitis in the control group. No recurrence was detected within the ESD group after a mean follow-up time of 11.2 months compared to three recurrences within a mean follow-up time of 27.7 months. Conclusions: From our preliminary experience, ESD is a promising alternative in the treatment of superficial duodenal PAs; however, further investigation is needed.
期刊介绍:
Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders.
Topics of interest include:
Management of pancreatic diseases
Third space endoscopy
Endoscopic resection
Therapeutic endoscopy
Therapeutic endosonography.