通过在纳米粒子-聚合物界面添加硼酸/硼酸酯动态键增强可注射纳米复合水凝胶的机械性能

IF 5 3区 化学 Q1 POLYMER SCIENCE
Gels Pub Date : 2024-10-02 DOI:10.3390/gels10100638
Jesús Sánchez, Jose Ulloa, Yessenia Oyarzún, Matías Ceballos, Carla Ruiz, Bruno Boury, Bruno F Urbano
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引用次数: 0

摘要

在可注射水凝胶中加入纳米粒子是一种众所周知的改善这些材料机械性能的技术。然而,聚合物基质和纳米粒子在机械性能上的显著差异会导致聚合物-纳米粒子界面出现局部应力集中。这种情况会导致颗粒与基体脱粘、空洞形成和材料失效等问题。这项研究引入了硼酸/硼酸酯动态共价键(DCB)作为能量耗散点,以缓解聚合物-纳米颗粒界面的应力集中。一旦硼酸基团被固定在二氧化硅纳米粒子(SiO2-BA)表面并融入海藻酸盐基质,纳米复合水凝胶就会表现出更强的粘弹性。与未改性的二氧化硅纳米粒子相比,在其表面添加硼酸的二氧化硅纳米粒子可改善水凝胶的结构完整性和稳定性。此外,与对照组相比,纳米粒子增强的水凝胶显示出更高的硬度和抗变形能力。这些特性取决于纳米粒子的浓度。注射测试表明,改性水凝胶具有剪切稀化行为,注射力在临床可接受的范围内,且恢复性能优越。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancing the Mechanical Properties of Injectable Nanocomposite Hydrogels by Adding Boronic Acid/Boronate Ester Dynamic Bonds at the Nanoparticle-Polymer Interface.

Incorporating nanoparticles into injectable hydrogels is a well-known technique for improving the mechanical properties of these materials. However, significant differences in the mechanical properties of the polymer matrix and the nanoparticles can result in localized stress concentrations at the polymer-nanoparticle interface. This situation can lead to problems such as particle-matrix debonding, void formation, and material failure. This work introduces boronic acid/boronate ester dynamic covalent bonds (DCBs) as energy dissipation sites to mitigate stress concentrations at the polymer-nanoparticle interface. Once boronic acid groups were immobilized on the surface of SiO2 nanoparticles (SiO2-BA) and incorporated into an alginate matrix, the nanocomposite hydrogels exhibited enhanced viscoelastic properties. Compared to unmodified SiO2 nanoparticles, introducing SiO2 nanoparticles with boronic acid on their surface improved the structural integrity and stability of the hydrogel. In addition, nanoparticle-reinforced hydrogels showed increased stiffness and deformation resistance compared to controls. These properties were dependent on nanoparticle concentration. Injectability tests showed shear-thinning behavior for the modified hydrogels with injection force within clinically acceptable ranges and superior recovery.

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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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