来自贯叶连翘的一种新的常萜苷和一种新的二苯甲酮衍生物及其体外细胞毒性活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-10-23 DOI:10.1016/j.fitote.2024.106276

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引用次数: 0

摘要

通过对贯叶连翘（Hypericum cerastioides）气生部分的植物化学研究，分离并鉴定出了一种新型常萜类化合物（1）和一种之前未曾描述过的二苯甲酮苷（3），以及 11 种已知的次级代谢产物（2、4-13）。根据大量的一维和二维核磁共振分析以及 HRESIMS，推断出了它们的结构。化合物 1 是一种罕见的具有八个碳原子的正茂萜烯衍生物。此外，还讨论了分离物的化学分类学意义。以多柔比星为参照药物，评估了化合物对 SW480、A375、DU145 和 MCF7 癌细胞株的体外细胞毒性活性。化合物 1 和 7 的细胞毒性较弱。

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A novel normonoterpene glycoside and a new benzophenone derivative from Hypericum cerastioides and their in vitro cytotoxic activities

Phytochemical investigations on the aerial parts of Hypericum cerastioides led to the isolation and identification of a novel normonoterpene (1) and a previously undescribed benzophenone glycoside (3) along with eleven known secondary metabolites (2, 4–13). Their structures were deduced based on extensive 1D and 2D NMR analyses as well as HRESIMS. Compound 1 is a rare type of normonoterpene derivative with eight carbon atoms. The chemotaxonomic significance of the isolates was also discussed. Compounds were evaluated for their in vitro cytotoxic activities against SW480, A375, DU145 and MCF7 cancer cell lines using doxorubicin as a reference drug. Compounds 1 and 7 demonstrated weak cytotoxicity.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.