外伤患者伤后使用阿片类镇痛药的情况:一项基于登记册的研究。

IF 3.5 2区 医学 Q1 ANESTHESIOLOGY
Henrik A Torp, Svetlana O Skurtveit, Ingebjørg Gustavsen, Jon M Gran, Leiv A Rosseland
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引用次数: 0

摘要

背景:阿片类镇痛药常用于治疗外伤后的急性和慢性疼痛。据报道,精神疾病合并症与疼痛加剧和持续使用阿片类药物有关。我们的目的是确定受伤后阿片类药物的使用程度,并评估受伤前使用抗抑郁药、苯二氮卓类药物和z-催眠药是否与受伤后阿片类药物使用增加有关:将奥斯陆大学医院创伤登记处 2005 年至 2014 年期间收录的 15 岁及以上创伤患者数据与挪威处方数据库的数据进行链接。我们确定了创伤后最初 90 天和 365 天内阿片类药物的发放情况,并确定了随后的持续使用情况。我们采用多变量逻辑回归法研究了受伤前和受伤后药物使用之间的关联:在 11,057 名患者中,有 3912 人(35.4%)在创伤后 90 天内使用过阿片类药物,有 4644 人(42.0%)在创伤后 365 天内使用过阿片类药物。在 9800 名之前未使用过阿片类药物的患者中,这一比例分别为 33.0% 和 39.0%。在受伤后首次发放阿片类药物一年后,9.6%的阿片类药物使用者和4.5%的新使用者被定义为持续使用者。受伤前苯二氮卓类药物和z-催眠药的使用与新的阿片类药物的持续使用有关(调整后的几率比[aOR]分别为2.25;95%置信区间[CI]为1.47-3.45和aOR为2.04;95%置信区间[CI]为1.33-3.13),而受伤前抗抑郁药物的使用与之无关(aOR为1.49;95%置信区间[CI]为0.97-2.30):结论:创伤后阿片类药物的使用非常普遍。结论:外伤后阿片类药物的使用非常普遍,但持续使用的情况有限,尤其是以前未使用过阿片类药物的患者。受伤前使用苯二氮卓或z-催眠药似乎会增加新的持续使用几率:这项以登记为基础的大型研究进一步丰富了有关创伤患者在院内护理之外使用阿片类药物的知识。研究表明,既往的药物治疗和开始阿片类药物治疗的性质可能会影响治疗效果。这将有助于指导临床医生为这一患者群体选择适当的疼痛治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Post-injury use of opioid analgesics in patients with traumatic injury: A registry-based study.

Background: Opioid analgesics are commonly used to treat acute and chronic pain following traumatic injury. Psychiatric comorbidity has been reported to be associated with increased pain and persistent opioid use. Our aims were to determine the extent of post-injury opioid use and assess whether pre-injury antidepressant, benzodiazepine, and z-hypnotic drug use is associated with increased post-injury opioid use.

Methods: Data on trauma patients aged 15 years and older included in the Oslo University Hospital Trauma Registry between 2005 and 2014 was linked to data from the Norwegian Prescription Database. We identified opioid dispensing within the first 90 and 365 days following trauma and determined subsequent persistent use. Multivariable logistic regression was applied to examine associations between pre- and post-injury drug use.

Results: 3912 of 11,057 patients (35.4%) had opioids dispensed within 90 days after trauma, and 4644 (42.0%) within 365 days. Among 9800 previously opioid-naïve, the proportions were 33.0% and 39.0%, respectively. One year after the first post-injury opioid dispensing, 9.6% of all opioid users and 4.5% of new users were defined as persistent users. Pre-injury benzodiazepine use and z-hypnotic use was associated with new persistent opioid use (adjusted odds ratio [aOR] 2.25; 95% confidence interval [CI] 1.47-3.45, and aOR 2.04; 95% CI 1.33-3.13, respectively), whereas pre-injury antidepressant use was not (aOR 1.49; 95% CI 0.97-2.30).

Conclusions: Opioid use after trauma is widespread. Development of persistent use is limited, particularly in previously opioid-naïve patients. Pre-injury benzodiazepine or z-hypnotic use seem to increase odds of new persistent use.

Significance statement: This large registry-based study adds to the body of knowledge on opioid use beyond in-hospital care in patients having sustained traumatic injury, a field which is scarcely investigated and not yet fully understood. It suggests that both previous drug therapy and the nature of opioid treatment initiation may affect outcome. This will help guide clinicians in selecting the appropriate pain management in this patient group.

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来源期刊
European Journal of Pain
European Journal of Pain 医学-临床神经学
CiteScore
7.50
自引率
5.60%
发文量
163
审稿时长
4-8 weeks
期刊介绍: European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.
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