皮质营养肿瘤中对库欣病鉴别诊断测试的反应性、肿瘤大小和体生长抑素受体 5 表达之间的相互关联。

IF 1.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine journal Pub Date : 2024-10-24 DOI:10.1507/endocrj.EJ24-0344

Karolina Budzen, Kosuke Mukai, Yuto Mitsui, Michio Otsuki, Atsunori Fukuhara, Satoru Oshino, Youichi Saitoh, Masaharu Kohara, Eiichi Morii, Iichiro Shimomura

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引用次数: 0

摘要

库欣病（CD）患者对鉴别诊断测试的反应性、皮质营养肿瘤的大小以及皮质营养肿瘤中体泌素受体（SSTR）5的表达存在差异。SSTR5 表达的差异对于确定 CD 的治疗靶点尤为重要。然而，SSTR5表达的前瞻性预测因素仍不清楚。因此，我们的目的是阐明包括 SSTR5 表达在内的这些 CD 临床特征之间的关系。我们对日本大阪大阪大学医院的 27 名住院 CD 患者进行了回顾性研究，调查了皮质营养瘤直径、ACTH 和皮质醇对 CD 鉴别诊断试验（CRH、去氨加压素 [DDAVP] 和大剂量地塞米松抑制试验 [HDDST]）的反应、ACTH/皮质醇指数和 SSTR5 免疫反应评分之间的关系。对鉴别诊断测试的反应、促肾上腺皮质激素/皮质醇指数、肿瘤直径和 SSTR5 表达有显著相关性（vs. 肿瘤直径[CRH：r = -0.54；DDAVP：r = -0.54；HDDST r = -0.67；促肾上腺皮质激素/皮质醇指数：r = 0.76；SSTR5：r = -0.61]，vs. SSTR5：r = -0.61）。CRH [DDAVP: r = 0.63, HDDST: r = 0.72, ACTH/cortisol index: r = -0.45; SSTR5: r = 0.56], vs. DDAVP [HDDST: r = 0.66; ACTH/cortisol index: r = -0.46；SSTR5：r = 0.76]，对 HDDST [ACTH/皮质醇指数：r = -0.62；SSTR5：r = 0.77]，ACTH/皮质醇指数对 SSTR5：r = -0.67）。通过 CRH 试验、DDAVP 试验、HDDST、ACTH/皮质醇指数和肿瘤直径预测 SSTR5 高表达的接收者操作特征曲线下面积分别为 0.79、0.87、0.80、0.71 和 0.71。CD鉴别诊断试验、促肾上腺皮质激素/皮质醇指数和皮质营养瘤直径具有识别皮质营养瘤中SSTR5表达的潜力。这些参数可能反映了皮质营养肿瘤的生物学特征。

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Mutual associations among responsiveness to differential diagnostic tests for Cushing's disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors.

There are differences in the responsiveness to differential diagnostic tests for Cushing's disease (CD), corticotroph tumor size, and the somatostatin receptor (SSTR) 5 expression in corticotroph tumors between CD patients. The differences in SSTR5 expression are particularly significant for identifying therapeutic targets for CD. However, prospective predictors of SSTR5 expression remain unclear. Thus, our objective was to elucidate the relationships among these clinical characteristics of CD, including SSTR5 expression. In 27 hospitalized patients with CD at Osaka University Hospital, Osaka, Japan, associations between corticotroph tumor diameter, the response of ACTH and cortisol to differential diagnostic tests for CD (CRH, desmopressin [DDAVP], and high-dose dexamethasone suppression test [HDDST]), the ACTH/cortisol index, and the SSTR5 immunoreactive score were retrospectively investigated. The response to differential diagnostic tests, ACTH/cortisol index, tumor diameter, and SSTR5 expression were significantly related (vs. tumor diameter [CRH: r = -0.54; DDAVP: r = -0.54; HDDST r = -0.67; ACTH/cortisol index: r = 0.76; SSTR5: r = -0.61], vs. CRH [DDAVP: r = 0.63, HDDST: r = 0.72, ACTH/cortisol index: r = -0.45; SSTR5: r = 0.56], vs. DDAVP [HDDST: r = 0.66; ACTH/cortisol index: r = -0.46; SSTR5: r = 0.76], vs. HDDST [ACTH/cortisol index: r = -0.62; SSTR5: r = 0.77], ACTH/cortisol index vs. SSTR5: r = -0.67). The areas under the receiver operating characteristic curve for the prediction of high SSTR5 expression via the CRH test, DDAVP test, HDDST, ACTH/cortisol index, and tumor diameter were 0.79, 0.87, 0.80, 0.71, and 0.71, respectively. Tests for differential diagnosis of CD, the ACTH/cortisol index, and the corticotroph tumor diameter have the potential for identifying SSTR5 expression in corticotroph tumors. These parameters may reflect the biological characteristics of corticotroph tumors.

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来源期刊

Endocrine journal 医学-内分泌学与代谢

CiteScore

4.30

自引率

5.00%

发文量

224

审稿时长

1.5 months

期刊介绍： Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.