用双源光子计数计算机断层扫描评估小型冠状动脉支架:不同扫描模式对模型图像质量和性能的影响。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Thomas Stein, Constantin von Zur Muhlen, Niklas Verloh, Till Schürmann, Tobias Krauss, Martin Soschynski, Dirk Westermann, Jana Taron, Elif Can, Christopher L Schlett, Fabian Bamberg, Christopher Schuppert, Muhammad Taha Hagar
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引用次数: 0

摘要

目的:该研究旨在评估双源光子计数探测器计算机断层扫描(PCD-CT)的可行性和图像质量,以评估在模型中不同采集模式下的小型冠状动脉支架:利用模拟患者平均水当量直径的模型设置,我们采用双源 PCD-CT 扫描仪的四种不同 CT 采集模式,检查了在硅管内充气的六种不同冠状动脉支架,支架尺寸从 2.0 毫米到 3.5 毫米不等:采用双源 PCD-CT 扫描仪的四种不同 CT 采集模式:"高间距"、"顺序"、"螺旋"(每种模式的准直度为 144 × 0.4 毫米,具有全光谱信息)和 "超高分辨率 (UHR)"(准直度为 120 × 0.2 毫米,无光谱信息)。图像质量和诊断可信度采用主观测量和客观测量进行评估,主观测量包括由两名独立放射科医生使用的 4 点视觉分级表(4 = 优秀;1 = 无诊断价值),客观测量包括半最大值全宽(FWHM):共采集了 24 张扫描图像,全部纳入分析。在所有 CT 采集模式中,UHR 模式获得的图像质量最高[中位数分数:4(四分位间距(IQR):3.67-4.00)](P = 0.0015,37.5% 被评为 "优秀"),其次是顺序模式[中位数分数:3.5(IQR:2.84-4.00)],P = 0.0326,再次是螺旋模式[中位数分数:3.0(IQR:2.53-3.47),P > 0.05]。高螺距模式的图像质量最低[中位数分数:2(IQR:1-3),P = 0.028]。同样,在评估支架通畅性方面,UHR 的诊断可信度最高,高螺距最低(分别为 P < 0.001)。所有采集模式对支架尺寸的测量都很准确,其中 UHR 模式的稳健性最高(FWHM 分别为顺序:0.926 ± 0.061 vs. 高螺距:0.990 ± 0.083 vs. 螺旋:0.962 ± 0.085 vs. UHR:0.941 ± 0.036,P = 无显著性):结论:使用 PCD-CT 技术评估小尺寸冠状动脉支架是可行的。结论:使用 PCD-CT 技术评估小尺寸冠状动脉支架是可行的,UHR 模式提供了卓越的图像质量和诊断信心,而所有模式都显示出一致和准确的测量结果:这些发现凸显了 PCD-CT 技术(尤其是 UHR 模式)在增强无创冠状动脉支架评估方面的潜力。指南建议心脏 CT 仅用于 3 毫米或更大的支架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating small coronary stents with dual-source photon-counting computed tomography: effect of different scan modes on image quality and performance in a phantom.

Purpose: The study aimed to assess the feasibility and image quality of dual-source photon-counting detector computed tomography (PCD-CT) in evaluating small-sized coronary artery stents with respect to different acquisition modes in a phantom model.

Methods: Utilizing a phantom setup mimicking the average patient's water-equivalent diameter, we examined six distinct coronary stents inflated in a silicon tube, with stent sizes ranging from 2.0 to 3.5 mm, applying four different CT acquisition modes of a dual-source PCD-CT scanner: "high-pitch," "sequential," "spiral" (each with collimation of 144 × 0.4 mm and full spectral information), and "ultra-high-resolution (UHR)" (collimation of 120 × 0.2 mm and no spectral information). Image quality and diagnostic confidence were assessed using subjective measures, including a 4-point visual grading scale (4 = excellent; 1 = non-diagnostic) utilized by two independent radiologists, and objective measures, including the full width at half maximum (FWHM).

Results: A total of 24 scans were acquired, and all were included in the analysis. Among all CT acquisition modes, the highest image quality was obtained for the UHR mode [median score: 4 (interquartile range (IQR): 3.67-4.00)] (P = 0.0015, with 37.5% rated as "excellent"), followed by the sequential mode [median score: 3.5 (IQR: 2.84-4.00)], P = 0.0326 and the spiral mode [median score: 3.0 (IQR: 2.53-3.47), P > 0.05]. The lowest image quality was observed for the high-pitch mode [median score: 2 (IQR: 1- 3), P = 0.028]. Similarly, diagnostic confidence for evaluating stent patency was highest for UHR and lowest for high-pitch (P < 0.001, respectively). Measurement of stent dimensions was accurate for all acquisition modes, with the UHR mode showing highest robustness (FWHM for sequential: 0.926 ± 0.061 vs. high-pitch: 0.990 ± 0.083 vs. spiral: 0.962 ± 0.085 vs. UHR: 0.941 ± 0.036, P = non-significant, respectively).

Conclusion: Assessing small-sized coronary stents using PCD-CT technology is feasible. The UHR mode offers superior image quality and diagnostic confidence, while all modes show consistent and accurate measurements.

Clinical significance: These findings highlight the potential of PCD-CT technology, particularly the UHR mode, to enhance non-invasive coronary stent evaluation. Confirmatory research is necessary to influence the guidelines, which recommend cardiac CT only for stents of 3 mm or larger.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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