血清自体表皮生长因子水平与绝经后妇女代谢相关性脂肪肝和高尿酸血症呈正相关

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases Pub Date : 2024-10-23 DOI:10.1159/000542061

Jie Zhang, Jiahui Hu, Yu Li, Xuefeng Zhou, Yini Ke, Yi Chen

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引用次数: 0

摘要

简介自体表皮生长因子是一种已知会影响能量代谢和脂质平衡的脂肪因子。我们的目的是评估绝经后妇女血清自体表皮生长因子在代谢相关性脂肪肝（MAFLD）和其他代谢紊乱中的水平：方法：纳入每年接受健康检查的绝经后妇女。方法：纳入接受年度健康检查的绝经后妇女，收集受试者的代谢和人口特征，包括年龄、性别、体重、身高、血压和生化指标。血清自体表皮生长因子水平通过酶联免疫吸附法测定：这项横断面研究包括 20 名绝经后妇女和 20 名年龄配对的健康对照组。MAFLD患者表现出明显的代谢紊乱，BMI和血压升高（P＜0.001），HDL-C降低（P＜0.05），肝损伤伴有ALT升高（P＜0.05）。据统计，MAFLD 组血清自体免疫球蛋白水平较高（253.1±52.1 vs. 202.2±53.2 ng/mL；P <；0.01），并与 ALT（P＜0.001）、GGT 和 BMI（P＜0.01）、SBP 和 TG（P＜0.05）呈正相关。高自旋糖苷组的代谢状态恶化，MAFLD比例更高，BMI（P＜0.01）和ALT（P＜0.05）更高。逻辑回归分析表明，血清自体免疫球蛋白水平可独立预测 MAFLD（OR 1.049，95% CI 1.001-1.098，P＜0.05），AUC 为 0.763。高尿酸血症组血清自体免疫球蛋白水平明显升高（257.3±60.9 vs. 214.5±49.4 ng/mL；P <；0.05），并与尿酸水平呈正相关（P＜0.01）。血清自体表皮生长因子也可作为高尿酸血症的诊断参数，其AUC为0.706：在绝经后妇女中，血清自体表皮生长因子水平在 MAFLD 中显著升高，并与多种代谢特征，尤其是高尿酸血症有关，因此可作为一种潜在的非侵入性生物标志物和治疗靶点。

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Serum Autotaxin Level Positively Associates with Metabolic-Associated Fatty Liver Disease and Hyperuricemia in Postmenopausal Women.

Introduction: Autotaxin (ATX) is an adipokine known to affect energy metabolism and lipid homeostasis. We aimed to evaluate serum ATX levels in metabolic-associated fatty liver disease (MAFLD) and other metabolic disorders in postmenopausal women.

Methods: Postmenopausal women who received an annual health examination were included. The metabolic and demographic characteristics of the subjects were collected, including age, gender, weight, height, blood pressure, and biochemical parameters. Serum ATX level was determined by ELISA.

Results: This cross-sectional includes 20 postmenopausal women and 20 age-paired healthy controls. MAFLD patients showed significant metabolic disturbance presented with increased body mass index (BMI), blood pressure (p < 0.001) and decreased high-density lipoprotein cholesterol (p < 0.05), as well as liver injury companied by elevated ALT (p < 0.05). Serum ATX levels were statistically higher in MAFLD (253.1 ± 52.1 vs. 202.2 ± 53.2 ng/mL; p < 0.01) and positively correlated with ALT (p < 0.001), γ-glutamyltransferase and BMI (p < 0.01), SBP and TG (p < 0.05). Higher ATX group demonstrated worsen metabolic states with greater proportion of MAFLD, higher BMI (p < 0.01), and ALT (p < 0.05). Logistic regression analysis revealed that serum ATX levels would positively independently predicted MAFLD (OR 1.049, 95% CI: 1.001-1.098, p < 0.05) with AUC of 0.763. Serum level of ATX is significantly elevated in hyperuricemia group (257.3 ± 60.9 vs. 214.5 ± 49.4 ng/mL; p < 0.05) and positively correlated with uric acid level (p < 0.01). Serum ATX would also act as diagnosing parameter of hyperuricemia with AUC of 0.706.

Conclusions: Among postmenopausal women, serum ATX level is significantly elevated in MAFLD and related to multiple metabolic characteristics, especially hyperuricemia, which would thus serve as a potential noninvasive biomarker as well as a therapeutic target.

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来源期刊

Digestive Diseases 医学-胃肠肝病学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.