揭开炎症性肠病中中性粒细胞胞外捕获物的神秘面纱:途径、生物标志物和有前景的疗法。

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yilin Wu, Jun Shen
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引用次数: 0

摘要

包括溃疡性结肠炎和克罗恩病在内的炎症性肠病(IBD)的发病涉及多种因素,其特点是粘膜持续发炎。然而,中性粒细胞在这一过程中的作用仍存在争议。中性粒细胞释放的细胞外捕获物(NET)由染色质、抗菌蛋白和氧化酶组成,可捕获病原体。它们还与各种免疫介导的疾病和血管疾病有关。NET 是肠道粘膜界面的重要防御机制,经常受到细菌、病毒和真菌的威胁。然而,它们也会导致炎症,加剧肠道细菌的失衡。最近的研究表明,NET 对 IBD 的发展有重大影响。以往的研究表明,在 IBD 患者的组织和血液样本中,以及在实验性结肠炎小鼠模型中,NETs 的含量都有所增加。因此,本综述将讨论 NET 是如何形成的,以及它们在 IBD 病理生理学中的作用。它还讨论了 NET 如何导致组织损伤并引发 IBD 相关并发症。此外,还需要非侵入性生物标志物来取代内窥镜等侵入性检查,以更好地评估疾病状况。鉴于 NET 在 IBD 病程进展中的关键作用,本综述将重点关注有助于预测 IBD 演变的潜在 NET 生物标志物。此外,本综述还确定了调节 NET 生成的潜在治疗靶点,这将扩大 IBD 的可用治疗方案范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies.

The development of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, involves various factors and is characterized by persistent inflammation of the mucosal lining. However, the role of neutrophils in this process remains controversial. Neutrophil extracellular traps (NETs), which consist of chromatin, antimicrobial proteins, and oxidative enzymes, are released by neutrophils to trap pathogens. They are also involved in various immune-mediated and vascular diseases. NETs act as a vital defense mechanisms at the gut-mucosal interface and are frequently exposed to bacterial, viral, and fungal threats. However, they can also contribute to inflammation and worsen imbalances in the gut bacteria. Recent studies have suggested that NETs have a significant impact on IBD development. Previous studies have shown increased levels of NETs in tissue and blood samples from patients with IBD, as well as in experimental colitis mouse models. Therefore, this review discusses how NETs are formed and their role in the pathophysiology of IBD. It discusses how NETs may lead to tissue damage and contribute to IBD-associated complications. Moreover, non-invasive biomarkers are needed to replace invasive procedures such as endoscopy to better evaluate the disease status. Given the crucial role of NETs in IBD progression, this review focuses on potential NET biomarkers that can help predict the evolution of IBD. Furthermore, this review identifies potential therapeutic targets for regulating NET production, which could expand the range of available treatment options for IBD.

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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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