Covid-19 相关神经系统损伤的潜在机制及其对女性生育能力的影响。

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2024-10-24 DOI:10.2174/0109298673333968241011092801

Chen-Yue Qian, Si-Ning Hu, Liu Huadong, Jing-Jin Liu

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引用次数: 0

摘要

超过 "急性 COVID-19 "阶段仍持续存在或恶化的体征和症状被称为 "长期 COVID"。这些患者更有可能出现多器官衰竭、再次入院和死亡。根据最新理论，长期的 COVID-19 症状可能是由自律神经系统（ANS）活动异常引起的，如血容量不足、脑干受累和自身免疫反应。此外，COVID-19 还可能导致女性生育能力受损，这也可能与炎症和免疫反应有关。目前，几乎没有针对长期 COVID 症状的治疗方法。本文回顾了 COVID-19 对神经系统和女性生育能力的主要影响，并提供了潜在的治疗方法。

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Potential Mechanisms of Covid-19 Related Nervous System Damage and Effects on Female Fertility.

Signs and symptoms that persist or worsen beyond the "acute COVID-19" stage are referred to as long-COVID. These patients are more likely to suffer from multiple organ failure, readmission, and mortality. According to a recent theory, long-lasting COVID-19 symptoms may be caused by abnormal autonomic nervous system (ANS) activity, such as hypovolemia, brain stem involvement, and autoimmune reactions. Furthermore, COVID-19 can also cause impaired fertility in women, which may also be related to inflammation and immune responses. Currently, few treatments are available for long-COVID symptoms. This article reviews the major effects of COVID-19 on the nervous system and female fertility, as well as offers potential treatment approaches.

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.