蛋白质受体-配体相互作用动力学定量测定的最新进展。

IF 4.2 2区 化学 Q1 CHEMISTRY, ANALYTICAL
Wei Xu, Dan Meng, Ming Li, Xinqian Wang, Chenyu Xu, Yifei Zhang, Dingqiang Lu, Ruijuan Ren
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引用次数: 0

摘要

受体与配体的结合对各种生物医学和生物化学过程、免疫反应和信号转导至关重要,是许多生物技术应用的基础。受体与配体之间的特异性结合是受体或配体分子生物功能的开始。因此,有必要对受体与配体相互作用动力学的定量测定方法进行总结性研究。本综述首先介绍了传统上描述受体与配体相互作用模式的动力学参数。然后,我们总结并分析了受体-配体相互作用动力学的定量测定方法,包括直接动力学测量、基于细胞学的测量、基于计算化学的测量以及受体-配体相互作用的单分子力谱技术测量。基于表面等离子体共振、表面增强拉曼光谱、光电化学、质谱结合分析、核磁共振技术和电化学方法的受体-配体相互作用动力学直接测量方法得到了进一步描述。这篇综述全面准确地描述了蛋白质受体与配体相互作用的动力学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advances in the Quantitative Determination of Protein Receptor-Ligand Interaction Kinetics.

Receptor-ligand binding, which is crucial to a variety of biomedical and biochemical processes, immune responses, and signal transduction, forms the basis for many biotechnological applications. The specific binding between a receptor and a ligand is the beginning of the biological function of the receptor or ligand molecule. Therefore, a summary study of methods for quantitative determination of receptor-ligand interaction kinetics is necessary. In this review, the kinetic parameters that traditionally describe the pattern of receptor-ligand interactions are first introduced. We then summarize and analyze methods for quantitative determination of receptor-ligand interaction kinetics, including direct kinetic measurements, cytology-based measurements, computational chemistry-based measurements, and single-molecule force spectrometry technique measurements of receptor-ligand interactions. Direct measurements of the kinetics of receptor-ligand interactions are further described in methods based on surface plasmon resonance, surface-enhanced Raman spectroscopy, photoelectrochemistry, mass spectrometry binding analyses, nuclear magnetic resonance technology, and electrochemical methods. This review provides a comprehensive and accurate description of the kinetic studies of protein receptor-ligand interactions.

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来源期刊
CiteScore
12.00
自引率
4.00%
发文量
137
审稿时长
6 months
期刊介绍: Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.
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