确诊 IBD 时患者报告的多维结果和生活质量:基于人群的初始队列研究。

IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Mohamed Attauabi, Gorm Roager Madsen, Flemming Bendtsen, Jakob Benedict Seidelin, Johan Burisch
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引用次数: 0

摘要

背景和目的:患者报告结果(PROs)对于评估治疗效果和估计炎症性肠病(IBD)的负担至关重要。我们对确诊 IBD 时的患者报告结果进行了调查:方法:我们在哥本哈根 IBD 初诊队列中评估了短式炎症性肠病问卷(SIBDQ)、IBD-残疾指数(IBD-DI)、慢性疾病治疗疲劳功能评估(FACIT-F)以及疾病活动相关的 PROs:结果:共招募了 203 名 UC 和 116 名 CD 患者。在确诊时,分别有 160 名(78.8%)和 99 名(85.3%)UC 和 CD 患者报告至少一项 PRO 存在中度至重度损伤(P=0.18),分别有 89 名(43.8%)和 74 名(63.8%)患者报告至少两项 PRO 存在中度至重度损伤(P结论:我们发现,在新诊断的 IBD 患者中,患者报告的疾病负担很重,这强调了在临床实践中警惕性监测 PRO 的重要性:本研究由诺和诺德基金会(Novo Nordisk Fonden)无限制资助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multidimensional Patient-Reported Outcomes and Quality of Life at Diagnosis of IBD: A Population-Based Inception Cohort Study.

Background and aims: Patient-reported outcomes (PROs) are pivotal in assessing treatment efficacy and estimating the burden of inflammatory bowel diseases (IBDs). We investigated PROs at the time of IBD diagnosis.

Methods: The Short Inflammatory Bowel Disease Questionnaire (SIBDQ), IBD Disability Index (IBD-DI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), and disease activity-related PROs were assessed in the Copenhagen IBD Inception Cohort, a prospective, population-based cohort of patients newly diagnosed with IBD between May 2021 and May 2023.

Results: A total of 203 ulcerative colitis (UC) and 116 Crohn's disease (CD) patients were recruited. At diagnosis, 160 (78.8%) and 99 (85.3%) patients with UC and CD, respectively, reported moderate-to-severe impairment in at least 1 PRO (P = .18), with 89 (43.8%) and 74 (63.8%), respectively, reporting moderate-to-severe impairment in at least 2 PROs (P < .01). Being female, the disease extent of UC, and extraintestinal manifestations were associated with impaired PROs. There were no differences found according to CD phenotype. FACIT-F, IBD-DI, and SIBDQ scores showed weak, but significant, correlations with the Mayo endoscopic score in UC, and the FACIT-F score with C-reactive protein. In CD, SIBDQ, IBD-DI, and FACIT-F correlated moderately with C-reactive protein and fecal calprotectin but not with the endoscopic severity of CD. None of the PROs correlated with iron, ferritin, or vitamin D levels. Among the most prevalent symptoms reported were fatigue, abdominal pain, urgency, and passing of blood in both CD and UC.

Conclusions: We found a substantial patient-reported disease burden in newly diagnosed IBD, underscoring the importance of vigilant PRO monitoring in clinical practice.

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来源期刊
CiteScore
16.90
自引率
4.80%
发文量
903
审稿时长
22 days
期刊介绍: Clinical Gastroenterology and Hepatology (CGH) is dedicated to offering readers a comprehensive exploration of themes in clinical gastroenterology and hepatology. Encompassing diagnostic, endoscopic, interventional, and therapeutic advances, the journal covers areas such as cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion. As a peer-reviewed publication, CGH features original articles and scholarly reviews, ensuring immediate relevance to the practice of gastroenterology and hepatology. Beyond peer-reviewed content, the journal includes invited key reviews and articles on endoscopy/practice-based technology, health-care policy, and practice management. Multimedia elements, including images, video abstracts, and podcasts, enhance the reader's experience. CGH remains actively engaged with its audience through updates and commentary shared via platforms such as Facebook and Twitter.
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