肝细胞癌衍生有机体:癌症研究的创新。

IF 5.1 2区 生物学 Q2 CELL BIOLOGY
Cells Pub Date : 2024-10-18 DOI:10.3390/cells13201726
Carlo Airola, Maria Pallozzi, Eleonora Cesari, Lucia Cerrito, Leonardo Stella, Claudio Sette, Felice Giuliante, Antonio Gasbarrini, Francesca Romana Ponziani
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引用次数: 0

摘要

肝细胞癌(HCC)是一种高度异质性的恶性肿瘤。它们的特点是具有特殊的肿瘤微环境和密集的血管。免疫细胞、内皮细胞和肿瘤细胞之间的信号传递非常重要,这导致使用传统的二维细胞培养法很难再现可靠的体外 HCC 模型。三维类器官肿瘤技术的出现忠实地复制了原始的癌症基因组、表观基因组和微环境,彻底改变了我们对多种恶性肿瘤发病机制和进展的认识。有机体更接近地模拟了体内环境和细胞相互作用,复制了细胞表面受体的空间组织和基因表达等因素,很可能成为选择疗法和评估肿瘤对治疗反应的重要工具。这篇综述旨在描述有机体作为体外模型在研究HCC发展、其与宿主免疫的相互作用、药物敏感性测试分析以及该领域目前的局限性等方面正在进行的和潜在的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatocellular-Carcinoma-Derived Organoids: Innovation in Cancer Research.

Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies. They are characterized by a peculiar tumor microenvironment and dense vascularization. The importance of signaling between immune cells, endothelial cells, and tumor cells leads to the difficult recapitulation of a reliable in vitro HCC model using the conventional two-dimensional cell cultures. The advent of three-dimensional organoid tumor technology has revolutionized our understanding of the pathogenesis and progression of several malignancies by faithfully replicating the original cancer genomic, epigenomic, and microenvironmental landscape. Organoids more closely mimic the in vivo environment and cell interactions, replicating factors such as the spatial organization of cell surface receptors and gene expression, and will probably become an important tool in the choice of therapies and the evaluation of tumor response to treatments. This review aimed to describe the ongoing and potential applications of organoids as an in vitro model for the study of HCC development, its interaction with the host's immunity, the analysis of drug sensitivity tests, and the current limits in this field.

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来源期刊
Cells
Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
9.90
自引率
5.00%
发文量
3472
审稿时长
16 days
期刊介绍: Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.
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