脱粘体上的 IP3 受体-KRAP 复合物:凋亡过程中的新角色

IF 4.3 2区 生物学 Q2 CELL BIOLOGY
Jan B. Parys
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引用次数: 0

摘要

IP3 受体(IP3R)是一种普遍表达的 Ca2+ 释放通道,位于内质网(ER)中。源自 IP3R 的 Ca2+ 信号可启动或调控大量细胞事件,包括细胞的生死过程,例如,从 ER 向线粒体释放过量 Ca2+ 可触发细胞凋亡。最近,Cho 等人(《当代生物学》,2024 年,DOI: 10.1016/j.cub.2024.08.057)证实,在上皮单层中,由 IP3Rs 引起的持续[Ca2+]升高是相邻凋亡细胞挤出上皮单层的原因。有趣的是,参与其中的 IP3R 通过 K-Ras 诱导的肌动蛋白相互作用蛋白(KRAP)与脱钙小体相关联。这项研究不仅凸显了 IP3R 在细胞凋亡中的新作用,而且还揭示了 KRAP 以及 KRAP 相关蛋白如何促进 IP3R 活性的调节,更广泛地说,它强调了相关蛋白在决定 IP3R 功能方面的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process
The IP3 receptor (IP3R) is a ubiquitously expressed Ca2+-release channel located in the endoplasmic reticulum (ER). Ca2+ signals originating from the IP3R initiate or regulate a plethora of cellular events, including cell life and death processes, e.g. exaggerated Ca2+ release from the ER to the mitochondria is a trigger for apoptosis. Recently, Cho et al. (Current Biology, 2024, DOI: 10.1016/j.cub.2024.08.057) demonstrated that in epithelial monolayers a sustained [Ca2+] elevation caused by the IP3Rs is responsible for the extrusion of adjacent apoptotic cells out of the epithelial monolayer. Interestingly, the IP3Rs involved are associated with the desmosomes via K-Ras-induced actin-interacting protein (KRAP). This study not only highlight a novel role of the IP3R in apoptosis, but also shed a new light on how KRAP -and by extension KRAP-related proteins- contribute to the regulation of IP3R activity and, more broadly, underscores the crucial role of associated proteins in determining the function of IP3Rs.
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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