在活检证实的 MASLD 队列中比较定量超声参数在测量肝脂肪变性方面的前瞻性诊断性能。

IF 1.8 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

British Journal of Radiology Pub Date : 2024-10-22 DOI:10.1093/bjr/tqae212

Kun Wang, Jingwen Bao, Minghui Wang, Yanjie Yu, Min Wang

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引用次数: 0

摘要

研究目的本研究旨在比较衰减成像（ATI）、剪切波弹性成像（SWE）和剪切波频散（SWD）在检测和分级代谢功能障碍相关性脂肪性肝病（MASLD）患者肝脂肪变性方面的诊断性能。方法：66 名经组织病理学确诊的代谢功能障碍相关性脂肪性肝病患者（平均年龄 41 岁 ± 12 岁；男性 36 人，女性 30 人）和 34 名年龄/性别匹配的健康志愿者（平均年龄 39 岁 ± 15 岁；男性 18 人，女性 16 人）被纳入本研究。进行了 ATI、SWE 和 SWD 检查。纤维化阶段、坏死性炎症活动和脂肪变性等级均经组织病理学证实。脂肪变性分级如下S0 (66%).我们比较了 ATI、SWE 和 SWD 在检测和分级肝脂肪变性方面的诊断性能：结果：衰减系数（AC）和SWD值在不同肝脏脂肪变性之间存在显著差异，且均与肝脏脂肪变性相关。SWE 无法区分肝脂肪变性。在检测和分级肝脂肪变性方面，ATI 的诊断性能优于 SWD。ATI 检测≥ S1、≥ S2 和 = S3 的接收器操作特征曲线下面积分别为 0.917（截断值为 0.69 dB/cm/MHz）、0.933（截断值为 0.74 dB/cm/MHz）和 0.870（截断值为 0.82 dB/cm/MHz）。SWD 值的 ROC 曲线下面积分别为 0.758（截止值为 10.79 m/s/kHz）、0.685（截止值为 12.64 m/s/kHz）和 0.722（截止值为 13.24 m/s/kHz）：与 SWE 和 SWD 相比，ATI 技术是检测和分级 MASLD 患者肝脏脂肪变性的可靠方法：我们比较了 ATI、SWE 和 SWD 对 MASLD 患者肝脏脂肪变性的检测和分级的诊断性能，以找到最佳的诊断参数。

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Prospective comparative diagnostic performance of quantitative ultrasound parameters for the measurement of hepatic steatosis in a biopsy-proven MASLD cohort.

Objectives: The aim of this study was to compare the diagnostic performance of attenuation imaging (ATI), shear wave elastography (SWE) and shear wave dispersion (SWD) for detecting and grading hepatic steatosis in patients with metabolic dysfunctionassociated steatotic liver disease (MASLD).

Methods: 66 patients with MASLD (mean age, 41 years ± 12; 36 men, 30 women) confirmed histopathologically and 34 healthy volunteers (mean age, 39 years ± 15; 18 men, 16 women) who were age/sex-matched were prospectively enrolled in this study. ATI, SWE and SWD examinations were performed. Fibrosis stage, necroinflammatory activity and steatosis grade were confirmed histopathologically. Steatosis was graded as follows: S0 (<5%); S1 (5-32%); S2 (33-66%) to S3 (>66%). We compared the diagnostic performance of ATI, SWE and SWD for detecting and grading hepatic steatosis.

Results: Both attenuation coefficient (AC) and SWD values were significantly different among the different hepatic steatosis, and both were correlated with hepatic steatosis. SWE could not distinguish hepatic steatosis. ATI had better diagnostic performance than SWD for detecting and grading hepatic steatosis. The area under the receiver operating characteristic (ROC) curve of ATI for detecting ≥ S1, ≥ S2, and = S3 were 0.917 (cut-off value of 0.69 dB/cm/MHz), 0.933 (cut-off value of 0.74 dB/cm/MHz), and 0.870 (cut-off value of 0.82 dB/cm/MHz), respectively. The area under the ROC curve of SWD value was 0.758 (cut-off value of 10.79 m/s/kHz), 0.685 (cut-off value of 12.64 m/s/kHz), and 0.722 (cut-off value of 13.24 m/s/kHz), respectively.

Conclusions: ATI technology is a reliable method for detecting and grading hepatic steatosis in patients with MASLD than SWE and SWD.

Advances in knowledge: We compared the diagnostic performance of ATI, SWE, SWD for detecting and grading hepatic steatosis in patients with MASLD in order to find the best diagnostic parameters.

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来源期刊

British Journal of Radiology 医学-核医学

CiteScore

5.30

自引率

3.80%

发文量

330

审稿时长

2-4 weeks

期刊介绍： BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences. Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896. Quick Facts: - 2015 Impact Factor – 1.840 - Receipt to first decision – average of 6 weeks - Acceptance to online publication – average of 3 weeks - ISSN: 0007-1285 - eISSN: 1748-880X Open Access option