美国老年人肺活量保留比值受损（PRISm）与认知功能之间的关系：收缩压的中介作用。

IF 3.4 2区医学 Q2 GERIATRICS & GERONTOLOGY

BMC Geriatrics Pub Date : 2024-10-24 DOI:10.1186/s12877-024-05349-8

Tao Ouyang, Jiajia Zhang, Yichen Tang, Qi Yang

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引用次数: 0

摘要

背景：最近的研究引起了人们对肺活量保留比值受损（PRISm）与认知功能下降之间关系的关注。高收缩压（SBP）是导致 PRISm 和痴呆症的已知风险因素。本研究旨在探讨 SBP 升高是否会介导 PRISm 与老年人认知功能之间的关系：本研究分析了 732 名年龄≥ 60 岁、在 2011-2012 年美国国家健康与营养调查（NHANES）中完成了肺活量测定和认知功能测试的参与者。研究采用多变量线性回归来评估 PRISm 与认知功能之间的关系，认知功能通过建立阿尔茨海默病登记联盟 (CERAD) 单词学习子测试、动物流畅性测试 (AFT)、数字符号替换测试 (DSST) 和整体认知测试来衡量。所有认知测试均以 z 分数建模，总体认知度则以 CERAD、AFT 和 DSST 的 z 分数之和计算。进行了中介分析，以检验 SBP 对 PRISm 与认知功能之间关联的中介效应：结果： PRISm 患者的 AFT（β = -0.300；95% 置信区间 [CI] = -0.479 到 -0.122；p = 0.001）、DSST（β = -0.157；95% CI = -0.309 到 -0.004；p = 0.044）和总体认知得分（β = -0.211；95% CI = -0.369 到 -0.053；p = 0.009）均低于肺活量正常的患者。SBP与AFT (β = -0.084; 95% CI = -0.162 to -0.005; p = 0.038)和DSST (β = -0.132; 95% CI = -0.207 to -0.057; p)显著相关：研究结果表明，SBP 在 PRISm 与老年人认知能力下降之间可能起着中介作用。

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The association between preserved ratio impaired spirometry (PRISm) and cognitive function among American older adults: the mediating role of systolic blood pressure.

Background: Recent studies have drawn attention to the association between preserved ratio impaired spirometry (PRISm) and cognitive function decline. High systolic blood pressure (SBP) is a known risk factor for both PRISm and dementia. This study aimed to investigate whether elevated SBP may mediate the relationship between PRISm and cognitive function in older adults.

Methods: This study analyzed 732 participants aged ≥ 60 years who had completed spirometry and cognitive function tests in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. Multivariable linear regression was employed to assess the relationship between PRISm and cognitive function, as measured through the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning sub-test, the Animal Fluency test (AFT), the Digit Symbol Substitution test (DSST), and global cognition tests. All cognitive tests were modeled as z-scores, and global cognition was calculated as the sum of the z-scores of the CERAD, AFT, and DSST. Mediation analyses were conducted to test the mediating effect of SBP on the association between PRISm and cognitive function.

Results: Participants with PRISm had lower AFT (β = -0.300; 95% confidence interval [CI] = -0.479 to -0.122; p = 0.001), DSST (β = -0.157; 95% CI = -0.309 to -0.004; p = 0.044), and global cognition scores (β = -0.211; 95% CI = -0.369 to -0.053; p = 0.009) than those with normal spirometry, after adjusting for all potential confounders. SBP was considerably associated with AFT (β = -0.084; 95% CI = -0.162 to -0.005; p = 0.038) and DSST (β = -0.132; 95% CI = -0.207 to -0.057; p < 0.001), mediating 7.9% and 18.0% of the association of PRISm with cognitive function, respectively. Furthermore, SBP mediated 17.1% of the association of PRISm with global cognition.

Conclusions: The findings suggested the potential role of SBP as a mediator of associations between PRISm and cognitive decline in older adults.

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来源期刊

BMC Geriatrics GERIATRICS & GERONTOLOGY-

CiteScore

5.70

自引率

7.30%

发文量

873

审稿时长

20 weeks

期刊介绍： BMC Geriatrics is an open access journal publishing original peer-reviewed research articles in all aspects of the health and healthcare of older people, including the effects of healthcare systems and policies. The journal also welcomes research focused on the aging process, including cellular, genetic, and physiological processes and cognitive modifications.