改善仔猪口服抗菌药暴露的给药策略。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Noslen Hernández, Béatrice B Roques, Marlène Z Lacroix, Didier Concordet
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引用次数: 0

摘要

背景:通过饮用水向牲畜输送抗菌药的普遍做法导致动物之间的接触水平存在很大差异,从而引发了对疾病爆发和抗菌药耐药性产生的担忧。造成这种差异的主要有三个关键因素:水管中药物浓度的波动、动物饮水行为的差异以及个体药代动力学参数的差异。本研究的目的是开发和评估一种根据猪的饮水模式调整给药方式的策略,从而在不增加药物总剂量的情况下改善药物分配:结果:我们的研究结果表明,基于动物饮水行为的几种给药策略可以有效增加动物的总体暴露量。这些策略包括增加暴露最少的动物的暴露量、提高平均暴露量、最大化大多数暴露良好的动物的暴露量,或增加暴露量以确保大量动物的药代动力学/药效学(PK/PD)标准达到阈值。总之,构建有效的饮用水分配策略需要优化特定的标准。本文详细介绍了各种标准和优化方法:本文通过实例证明,将饮水行为纳入阿莫西林的给药过程中,可提高达到 AUC/MIC 比值大于 25h 的仔猪比例。具体而言,对于多杀性巴氏杆菌,该比例从 30% 上升到至少 60%,而对于胸膜肺炎放线杆菌,该比例从 20% 上升到 70% 以上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Delivery strategies to improve piglets exposure to oral antimicrobials.

Background: The widespread practice of delivering antimicrobials through drinking water to livestock leads to considerable variability in exposure levels among animals, raising concerns regarding disease outbreaks and the emergence of antimicrobial resistance. This variability is primarily driven by three pivotal factors: fluctuations in drug concentration within water pipes, variances in drinking behavior among animals, and differences in individual pharmacokinetic parameters. The objective of this study is to develop and evaluate a strategy that tailors medication delivery based on the drinking patterns of pigs, aiming to improve medication distribution without increasing the overall dose of medication.

Results: Our results demonstrate that several distribution strategies based on the animals' drinking behavior can effectively increase their overall exposure. These strategies include increasing the exposure of the least exposed animals, raising the average exposure, maximizing the exposure of the majority of the well-exposed animals, or increasing exposure to ensure that a Pharmacokinetics/Pharmacodynamics (PK/PD) criterion reaches a threshold value for a large number of the animals. In summary, constructing an effective distribution strategy for drinking water requires optimizing a specific criterion. The various criteria and methods for optimizing then are detailed.

Conclusions: As examples, this article demonstrate that incorporating the drinking behavior into the delivery of amoxicillin results in an increase in the percentage of piglets reaching an AUC/MIC ratio greater than 25h. Specifically, with Pasteurella multocida, the percentage rises from 30 % to at least 60 % , while with Actinobacillus pleuropneumoniae, it increases from 20 % to more than 70 % .

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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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