压力诱导的核仁进化：核糖体基因间间隔（rIGS）转录本的作用

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-10-20 DOI:10.3390/biom14101333

Anastasia A Gavrilova, Margarita V Neklesova, Yuliya A Zagryadskaya, Irina M Kuznetsova, Konstantin K Turoverov, Alexander V Fonin

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引用次数: 0

摘要

20 多年前，人们已经清楚地认识到，核仁不仅具有组装核糖核酸颗粒这一最重要的生物学功能，而且还是许多细胞过程的关键控制者，参与细胞对压力的适应。核仁的多功能性源于其生物发生的特殊性。核仁是通过液-液相分离（LLPS）形成的多层生物分子凝聚物。在这篇综述中，我们将重点讨论细胞应激过程中核仁发生的变化、核仁对异常和应激条件反应的分子特征，以及从核糖体 DNA 基因间间隔区（IGS rDNA）转录的长非编码 RNA 的作用。

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Stress-Induced Evolution of the Nucleolus: The Role of Ribosomal Intergenic Spacer (rIGS) Transcripts.

It became clear more than 20 years ago that the nucleolus not only performs the most important biological function of assembling ribonucleic particles but is also a key controller of many cellular processes, participating in cellular adaptation to stress. The nucleolus's multifunctionality is due to the peculiarities of its biogenesis. The nucleolus is a multilayered biomolecular condensate formed by liquid-liquid phase separation (LLPS). In this review, we focus on changes occurring in the nucleolus during cellular stress, molecular features of the nucleolar response to abnormal and stressful conditions, and the role of long non-coding RNAs transcribed from the intergenic spacer region of ribosomal DNA (IGS rDNA).

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.