远程监测睡眠期间交感神经失衡及其对心血管风险评估的影响:系统回顾

IF 3.8 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Valerie A A van Es, Ignace L J de Lathauwer, Hareld M C Kemps, Giacomo Handjaras, Monica Betta
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引用次数: 0

摘要

夜间交感神经功能亢进是心血管疾病的早期指标,这就强调了对睡眠期间自律神经功能进行可靠的远程患者监测(RPM)的重要性。要做到有效,RPM 系统必须准确、非侵入性和具有成本效益。本综述评估了用于跟踪夜间自律神经系统 (ANS) 活动的非侵入性技术、指标和算法,评估了它们与冠心病的相关性以及集成到 RPM 系统中的可行性。通过系统性检索,从最初的 169 篇出版物中发现了 18 项相关研究,并提取了有关研究设计、人群特征、技术类型和 CV 影响的数据。审查的方式包括电极(如脑电图 (EEG)、心电图 (ECG)、多导睡眠图 (PSG))、光学传感器(如光电血压计 (PPG)、外周动脉张力 (PAT))、球心电图 (BCG)、摄像头、雷达和加速计。心率变异性(HRV)和血压(BP)成为最有前途的 RPM 指标,可全面了解睡眠期间的自律神经系统功能和血管健康状况。虽然电极可提供精确的心率变异数据,但仍具有侵入性,而 PPG 等光学传感器则显示出多模态监测的潜力,包括心率变异、SpO2 以及动脉僵硬度和血压的估计值。BCG 和摄像头等非侵入式方法有望用于心率和呼吸频率估算,但不太适合连续心率变异监测。总之,心率变异和血压是最可行的 RPM 指标,基于 PPG 的系统在非侵入性、连续监测多种模式方面大有可为。还需要进一步研究,以提高准确性、可行性,并与自律神经功能的直接测量方法(如微神经电图)进行对比验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Remote Monitoring of Sympathovagal Imbalance During Sleep and Its Implications in Cardiovascular Risk Assessment: A Systematic Review.

Nocturnal sympathetic overdrive is an early indicator of cardiovascular (CV) disease, emphasizing the importance of reliable remote patient monitoring (RPM) for autonomic function during sleep. To be effective, RPM systems must be accurate, non-intrusive, and cost-effective. This review evaluates non-invasive technologies, metrics, and algorithms for tracking nocturnal autonomic nervous system (ANS) activity, assessing their CV relevance and feasibility for integration into RPM systems. A systematic search identified 18 relevant studies from an initial pool of 169 publications, with data extracted on study design, population characteristics, technology types, and CV implications. Modalities reviewed include electrodes (e.g., electroencephalography (EEG), electrocardiography (ECG), polysomnography (PSG)), optical sensors (e.g., photoplethysmography (PPG), peripheral arterial tone (PAT)), ballistocardiography (BCG), cameras, radars, and accelerometers. Heart rate variability (HRV) and blood pressure (BP) emerged as the most promising metrics for RPM, offering a comprehensive view of ANS function and vascular health during sleep. While electrodes provide precise HRV data, they remain intrusive, whereas optical sensors such as PPG demonstrate potential for multimodal monitoring, including HRV, SpO2, and estimates of arterial stiffness and BP. Non-intrusive methods like BCG and cameras are promising for heart and respiratory rate estimation, but less suitable for continuous HRV monitoring. In conclusion, HRV and BP are the most viable metrics for RPM, with PPG-based systems offering significant promise for non-intrusive, continuous monitoring of multiple modalities. Further research is needed to enhance accuracy, feasibility, and validation against direct measures of autonomic function, such as microneurography.

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来源期刊
Bioengineering
Bioengineering Chemical Engineering-Bioengineering
CiteScore
4.00
自引率
8.70%
发文量
661
期刊介绍: Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering
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