Fatma Ben Abdessalem, Taieb Ach, Nadia Ghariani Fetoui, Emna Mraihi, Asma Ben Abdelkarim
{"title":"了解患有多囊卵巢综合征的北非女性的痤疮临床和荷尔蒙特征。","authors":"Fatma Ben Abdessalem, Taieb Ach, Nadia Ghariani Fetoui, Emna Mraihi, Asma Ben Abdelkarim","doi":"10.1007/s00403-024-03466-3","DOIUrl":null,"url":null,"abstract":"<div><p>Polycystic ovary syndrome (PCOS) is the leading endocrine disorder in young women of childbearing age. Dermatological issues, particularly acne, are a major reason for medical consultations. The aim of this study is to determine the prevalence of PCOS in patients presenting with acne as their main dermatological complaint and to compare the metabolic and hormonal clinical characteristics of acne patients with PCOS to those with isolated acne. This was a prospective study with analytical aims, carried out in the Endocrinology Department and the Dermatology Department of Farhat Hached University Hospital in Sousse. The study included patients seeking treatment for acne from January 2023 to January 2024, divided into two groups: those with confirmed PCOS (G1) and those with isolated acne (G2). All patients underwent hormonal assessment and ovarian ultrasound. We conducted a study involving 212 patients. We found that 65.6% of acne patients had been diagnosed with PCOS. Nodular lesions were significantly more frequent in ‘PCOS’ (<b><i>p</i></b> = <b>0.02</b>). Acne was linked with hirsutism, which was more prevalent in ‘PCOS’ (94.2% ‘PCOS’ vs. 67.1% ‘isolated acne’), as well as androgenic alopecia (51% ‘PCOS’ vs. 21.9% ‘isolated acne’) (<b><i>p</i></b> < <b>10</b><sup><b>− 3</b></sup>). ‘PCOS’ showed evidence of biological hyperandrogenism, with a mean testosterone level of 0.72 ± 0.27 ng/mL, significantly higher than in ‘isolated acne’. The LH/FSH ratio was greater than 1 in 72.7% of cases in ‘PCOS’, demonstrating a significant difference compared to ‘isolated acne’, where it was greater than 1 in 24.7% of cases (<b><i>p</i></b> < <b>10</b><sup><b>− 3</b></sup>). In our study, acne in ‘PCOS’ appeared to be more severe and was associated with hypertestosteronemia (<b>p = 0.041</b>) and hyperprolactinemia (<b>p = 0.008</b>). According to our results, phenotype A was the most likely to cause severe acne (<b>p = 0.043</b>). Our work is unique in that it brings to light this hidden aspect of the dermatological impact of PCOS, prompting physicians to screen for this endocrine disorder in all adult women seeking acne treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterizing clinical and hormonal profiles of acne in north African women with polycystic ovary syndrome\",\"authors\":\"Fatma Ben Abdessalem, Taieb Ach, Nadia Ghariani Fetoui, Emna Mraihi, Asma Ben Abdelkarim\",\"doi\":\"10.1007/s00403-024-03466-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Polycystic ovary syndrome (PCOS) is the leading endocrine disorder in young women of childbearing age. Dermatological issues, particularly acne, are a major reason for medical consultations. The aim of this study is to determine the prevalence of PCOS in patients presenting with acne as their main dermatological complaint and to compare the metabolic and hormonal clinical characteristics of acne patients with PCOS to those with isolated acne. This was a prospective study with analytical aims, carried out in the Endocrinology Department and the Dermatology Department of Farhat Hached University Hospital in Sousse. The study included patients seeking treatment for acne from January 2023 to January 2024, divided into two groups: those with confirmed PCOS (G1) and those with isolated acne (G2). All patients underwent hormonal assessment and ovarian ultrasound. We conducted a study involving 212 patients. We found that 65.6% of acne patients had been diagnosed with PCOS. Nodular lesions were significantly more frequent in ‘PCOS’ (<b><i>p</i></b> = <b>0.02</b>). Acne was linked with hirsutism, which was more prevalent in ‘PCOS’ (94.2% ‘PCOS’ vs. 67.1% ‘isolated acne’), as well as androgenic alopecia (51% ‘PCOS’ vs. 21.9% ‘isolated acne’) (<b><i>p</i></b> < <b>10</b><sup><b>− 3</b></sup>). ‘PCOS’ showed evidence of biological hyperandrogenism, with a mean testosterone level of 0.72 ± 0.27 ng/mL, significantly higher than in ‘isolated acne’. The LH/FSH ratio was greater than 1 in 72.7% of cases in ‘PCOS’, demonstrating a significant difference compared to ‘isolated acne’, where it was greater than 1 in 24.7% of cases (<b><i>p</i></b> < <b>10</b><sup><b>− 3</b></sup>). In our study, acne in ‘PCOS’ appeared to be more severe and was associated with hypertestosteronemia (<b>p = 0.041</b>) and hyperprolactinemia (<b>p = 0.008</b>). According to our results, phenotype A was the most likely to cause severe acne (<b>p = 0.043</b>). Our work is unique in that it brings to light this hidden aspect of the dermatological impact of PCOS, prompting physicians to screen for this endocrine disorder in all adult women seeking acne treatment.</p></div>\",\"PeriodicalId\":8203,\"journal\":{\"name\":\"Archives of Dermatological Research\",\"volume\":\"316 10\",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-10-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Dermatological Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00403-024-03466-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Dermatological Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00403-024-03466-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Characterizing clinical and hormonal profiles of acne in north African women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the leading endocrine disorder in young women of childbearing age. Dermatological issues, particularly acne, are a major reason for medical consultations. The aim of this study is to determine the prevalence of PCOS in patients presenting with acne as their main dermatological complaint and to compare the metabolic and hormonal clinical characteristics of acne patients with PCOS to those with isolated acne. This was a prospective study with analytical aims, carried out in the Endocrinology Department and the Dermatology Department of Farhat Hached University Hospital in Sousse. The study included patients seeking treatment for acne from January 2023 to January 2024, divided into two groups: those with confirmed PCOS (G1) and those with isolated acne (G2). All patients underwent hormonal assessment and ovarian ultrasound. We conducted a study involving 212 patients. We found that 65.6% of acne patients had been diagnosed with PCOS. Nodular lesions were significantly more frequent in ‘PCOS’ (p = 0.02). Acne was linked with hirsutism, which was more prevalent in ‘PCOS’ (94.2% ‘PCOS’ vs. 67.1% ‘isolated acne’), as well as androgenic alopecia (51% ‘PCOS’ vs. 21.9% ‘isolated acne’) (p < 10− 3). ‘PCOS’ showed evidence of biological hyperandrogenism, with a mean testosterone level of 0.72 ± 0.27 ng/mL, significantly higher than in ‘isolated acne’. The LH/FSH ratio was greater than 1 in 72.7% of cases in ‘PCOS’, demonstrating a significant difference compared to ‘isolated acne’, where it was greater than 1 in 24.7% of cases (p < 10− 3). In our study, acne in ‘PCOS’ appeared to be more severe and was associated with hypertestosteronemia (p = 0.041) and hyperprolactinemia (p = 0.008). According to our results, phenotype A was the most likely to cause severe acne (p = 0.043). Our work is unique in that it brings to light this hidden aspect of the dermatological impact of PCOS, prompting physicians to screen for this endocrine disorder in all adult women seeking acne treatment.
期刊介绍：
Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
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