同源二聚体向异源二聚体过渡的建设性中性进化。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-10-23 DOI:10.1016/j.tibs.2024.10.003

Lin Chou, Carly J Houghton, Aaron Wacholder, Anne-Ruxandra Carvunis

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引用次数: 0

摘要

在进化过程中，大生物大分子的复杂化（如同源二聚体向异源二聚体的转变）很常见。这种复合是否总是适应性的？最近，Després 等人利用大规模实验和深入的生化分析证明，强制性异源二聚体可以通过中性、非适应性事件从同源二聚体进化而来，并量化了这种转变所需的关键参数。

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Constructive neutral evolution of homodimer to heterodimer transition.

Complexification of macrobiomolecules, such as homodimer to heterodimer transitions, are common during evolution. Is such complexification always adaptive? Using large-scale experiments and in-depth biochemical analyses, Després et al. recently demonstrated that an obligate heterodimer can evolve from a homodimer through neutral, nonadaptive events, and quantified key parameters required for such transitions.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.