Wnt 细胞表面信号体及其生物生成的线索。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-10-22 DOI:10.1016/j.tibs.2024.09.007

Philip Schmiege, Xiaochun Li

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引用次数: 0

摘要

Wnt 形态诱导因子通过结合细胞外受体诱导信号传导。在此，我们讨论了最近的几项结构研究，这些研究显示了 Wnt 如何与其受体 frizzled (FZD) 和低密度脂蛋白受体相关蛋白 5/6 (LRP5/6)结合，Cachd1 如何被证明是 Wnt 信号传导的另一种启动器，以及脂质化 Wnt 如何产生并从细胞中分泌出来。

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Clues into Wnt cell surface signalosomes and its biogenesis.

Wnt morphogens induce signaling via binding their extracellular receptors. Here, we discuss several recent structural studies showing how Wnts engage their receptors frizzled (FZD) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6), how Cachd1 has been shown as an alternative initiator of Wnt signaling, and how lipidated Wnt may be produced and secreted from the cell.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.