从药物中提取药物：对成熟概念的新化学见解。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-10-22 DOI:10.1016/j.drudis.2024.104212

Eloy Lozano Baró , Federica Catti , Carolina Estarellas , Ouldouz Ghashghaei , Rodolfo Lavilla

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引用次数: 0

摘要

从已上市的药物中开发出新药是药物发现中一种行之有效的成功方法。我们为这一领域提供了一个统一的视角，重点关注相关方法的新化学方面：(a) 原始药物的化学转化（后期修饰、分子编辑），(b) 原药策略，(c) 将再利用作为开发新命中药物/先导药物的工具。重点特别放在药物的分子结构及其合成可行性上。实验进展与新的计算方法（包括人工智能方法）相结合，为从药物概念到药物进化铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drugs from drugs: New chemical insights into a mature concept

Developing new drugs from marketed ones is a well-established and successful approach in drug discovery. We offer a unified view of this field, focusing on the new chemical aspects of the involved approaches: (a) chemical transformation of the original drugs (late-stage modifications, molecular editing), (b) prodrug strategies, and (c) repurposing as a tool to develop new hits/leads. Special focus is placed on the molecular structure of the drugs and their synthetic feasibility. The combination of experimental advances and new computational approaches, including artificial intelligence methods, paves the way for the evolution of the drugs from drugs concept.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.