早期复原力和表观遗传老化:为期 31 年的前瞻性芬兰青年研究结果。

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Aging Cell Pub Date : 2024-10-25 DOI:10.1111/acel.14394
Aino Saarinen, Saara Marttila, Pashupati P. Mishra, Leo-Pekka Lyytikäinen, Binisha Hamal Mishra, Emma Raitoharju, Nina Mononen, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Liisa Keltikangas-Järvinen
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引用次数: 0

摘要

越来越多的证据表明,早期逆境和恶劣的家庭环境与表观遗传老化有关。我们研究了早期社会心理复原力是否与成年后的表观遗传老化有关。我们使用了以人口为基础的芬兰青年数据(n = 1593)。我们在 1980-1989 年期间对五大领域的早期社会心理复原力进行了评估:(1) 心理力量指数(家庭/一般/学校中的自尊、感知到的家庭影响可能性、内部生活控制),(2) 社会满意度指数(感知到的家庭/朋友支持和生活满意度),(3) 业余时间活动指数(爱好和体能),(4) 负责任健康行为指数(不经常吸烟或饮酒),(5) 学校生涯指数(学校成绩和适应性)。表观遗传年龄是根据 2011 年的血样计算得出的,分析使用了年龄偏差变量(AgeDevHannum、AgeDevHorvath、AgeDevPheno、AgeDevGrim)和 DunedinPACE。协变量包括早期家庭环境、精神分裂症和重度抑郁症的多基因风险评分、成年期教育和成年期健康行为。所有早期复原力指数都与成年后较低水平的表观遗传老化有关,其中与 AgeDevGrim 和 DunedinPACE 的关系最为一致。尤其是心理强度和社会满意度的关联似乎是非线性的。在一个较小的子样本(n = 289)中,在 25 年的随访中,早期复原力高的人与 AgeDevGrim 水平低的人有关,而 AgeDevGrim 的 "基线 "水平高的人与 AgeDevGrim 水平低的人有关。总之,早期复原力似乎与成年后较低水平的表观遗传老化有关。我们的研究结果初步表明,早期复原力可能会增加普通人群中 "表观遗传老化的平等性"。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up

Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up

Evidence is accumulating on the connection of early adversities and harsh family environment with epigenetic ageing. We investigated whether early psychosocial resilience is associated with epigenetic ageing in adulthood. We used the population-based Young Finns data (n = 1593). Early psychosocial resilience was assessed in 1980–1989 across five broad domains: (1) index of psychological strength (self-esteem at home/in general/at school, perceived possibilities to influence at home, internal life control), (2) index of social satisfaction (perceived support from family/friends and life satisfaction), (3) index of leisure time activities (hobbies and physical fitness), (4) index of responsible health behaviors (infrequent smoking or alcohol consumption), and (5) index of school career (school grades and adaptation). Epigenetic ages were calculated for blood samples from 2011, and the analyses were performed with variables describing age deviation (AgeDevHannum, AgeDevHorvath, AgeDevPheno, AgeDevGrim) and DunedinPACE. Covariates included early family environment, polygenic risk scores for schizophrenia and major depression, adulthood education, and adulthood health behaviors. All of the early resilience indexes were associated with lower levels of epigenetic ageing in adulthood, most consistently with AgeDevGrim and DunedinPACE. The associations of psychological strength and social satisfaction, in particular, seemed to be non-linear. In a smaller subsample (n = 289), high early resilience was related to lower AgeDevGrim over a 25-year follow-up in those who had high “baseline” levels of AgeDevGrim. In conclusion, early resilience seems to associate with lower level of epigenetic ageing in adulthood. Our results tentatively suggest that early resilience may increase “equality in epigenetic ageing” in a general population.

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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
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