不同组织鳞状细胞癌的分子和细胞动态变化

IF 7.5 1区 生物学 Q1 CELL BIOLOGY
Matthew R. Kudelka, Yonit Lavin, Siman Sun, Elaine Fuchs
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引用次数: 0

摘要

鳞状细胞癌(SCC)发生于皮肤、头颈部、肺部、食道和宫颈,是最常见的癌症之一,也是癌症发病率和死亡率的常见原因。尽管起源的分层上皮组织各不相同,但越来越多的证据表明,SCCs 具有共同的生物通路。随着分子技术的不断突破,新的 SCC 治疗模式也应运而生,包括免疫疗法和靶向疗法。本综述比较了来自不同解剖部位的 SCC 的共性和差异,包括风险因素和遗传学,以及驱动肿瘤发生的细胞和分子程序。我们回顾了具有里程碑意义的发现:"癌症干细胞"(CSCs)启动并繁殖了SCCs及其基因和转化调控程序。这使人们认识到,CSCs 与免疫系统之间的相互作用在侵袭和抗药性方面发挥着关键作用。在此,我们回顾了在我们对这些上皮癌的认识上取得的这些令人兴奋的进展所产生的 SCC 的统一原则。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular and cellular dynamics of squamous cell carcinomas across tissues
Squamous cell carcinomas (SCCs), arising from the skin, head and neck, lungs, esophagus, and cervix, are collectively among the most common cancers and a frequent cause of cancer morbidity and mortality. Despite distinct stratified epithelial tissues of origin, converging evidence points toward shared biologic pathways across SCCs. With recent breakthroughs in molecular technologies have come novel SCC treatment paradigms, including immunotherapies and targeted therapy. This review compares commonalities and differences across SCCs from different anatomical sites, including risk factors and genetics, as well as cellular and molecular programs driving tumorigenesis. We review landmark discoveries of the “cancer stem cells” (CSCs) that initiate and propagate SCCs and their gene and translational regulation programs. This has led to an appreciation that interactions between CSCs and the immune system play key roles in invasion and therapeutic resistance. Here, we review the unifying principles of SCCs that have emerged from these exciting advances in our understanding of these epithelial cancers.
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来源期刊
Genes & development
Genes & development 生物-发育生物学
CiteScore
17.50
自引率
1.90%
发文量
71
审稿时长
3-6 weeks
期刊介绍: Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).
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