人体骨骼肌在 5 天干浸泡后力量损失的分子决定因素

IF 8.9 1区医学

Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2024-10-25 DOI:10.1002/jcsm.13559

Mathias Velarde, Michel-Yves Sempore, Valentine Allibert, Valérie Montel, Josiane Castells, Loïc Treffel, Angèle Chopard, Thomas Brioche, Laetitia Cochon, Jérome Morel, Bruno Bastide, Anne-Cécile Durieux, Laurence Stevens, Damien Freyssenet

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引用次数: 0

摘要

在地球轨道上的宇航员会经历微重力，导致骨骼肌质量和功能下降。在地球上，模拟微重力的模型显示，肌肉力量的损失程度大于肌肉质量的损失。这种不成比例的肌肉力量损失背后的原因仍不甚明了。在本研究中，我们假设在骨骼肌质量损失的同时，编码静息膜电位、兴奋-收缩耦合和 Ca2+ 处理的关键决定因子的基因表达谱的改变也会导致骨骼肌力量的下降。

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Molecular determinants of skeletal muscle force loss in response to 5 days of dry immersion in human

Astronauts in Earth's orbit experience microgravity, resulting in a decline of skeletal muscle mass and function. On Earth, models simulating microgravity have shown that the extent of the loss in muscle force is greater than the loss in muscle mass. The reasons behind this disproportionate loss of muscle force are still poorly understood. In the present study, we hypothesize that alongside the loss in skeletal muscle mass, modifications in the expression profile of genes encoding critical determinants of resting membrane potential, excitation-contraction coupling and Ca²⁺ handling contribute to the decline in skeletal muscle force.

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来源期刊

Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine

自引率

12.40%

发文量

期刊介绍： The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.