哺乳动物运动纤毛中两种同源驱动蛋白的不同作用

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-10-24 DOI:10.1083/jcb.202409214

Kaiming Xu,Ming Li,Guangshuo Ou

{"title":"哺乳动物运动纤毛中两种同源驱动蛋白的不同作用","authors":"Kaiming Xu,Ming Li,Guangshuo Ou","doi":"10.1083/jcb.202409214","DOIUrl":null,"url":null,"abstract":"How do the two kinesin-9 members Kif6 and Kif9 function in mammalian cilia? Ou and colleagues discuss new work from Fang et al. (https://doi.org/10.1083/jcb.202312060) showing that Kif6 is an active motor while Kif9 serves as a stationary regulator, both of which are essential for cilia motility.","PeriodicalId":15211,"journal":{"name":"Journal of Cell Biology","volume":"1 1","pages":""},"PeriodicalIF":7.4000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Distinct roles of two homologous kinesins in mammalian motile cilia.\",\"authors\":\"Kaiming Xu,Ming Li,Guangshuo Ou\",\"doi\":\"10.1083/jcb.202409214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"How do the two kinesin-9 members Kif6 and Kif9 function in mammalian cilia? Ou and colleagues discuss new work from Fang et al. (https://doi.org/10.1083/jcb.202312060) showing that Kif6 is an active motor while Kif9 serves as a stationary regulator, both of which are essential for cilia motility.\",\"PeriodicalId\":15211,\"journal\":{\"name\":\"Journal of Cell Biology\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":7.4000,\"publicationDate\":\"2024-10-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cell Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1083/jcb.202409214\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1083/jcb.202409214","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

驱动蛋白-9 的两个成员 Kif6 和 Kif9 在哺乳动物纤毛中是如何发挥作用的？欧文及其同事讨论了方等人(https://doi.org/10.1083/jcb.202312060)的新研究，该研究显示 Kif6 是一种主动马达，而 Kif9 则是一种静止调节器，两者对纤毛运动都至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Distinct roles of two homologous kinesins in mammalian motile cilia.

How do the two kinesin-9 members Kif6 and Kif9 function in mammalian cilia? Ou and colleagues discuss new work from Fang et al. (https://doi.org/10.1083/jcb.202312060) showing that Kif6 is an active motor while Kif9 serves as a stationary regulator, both of which are essential for cilia motility.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.