TMEM63B 在膜结构发生变化时扰乱磷脂

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-10-25 DOI:10.1038/s41594-024-01421-4

引用次数: 0

摘要

磷脂在质膜脂质双分子层上的分布对各种细胞功能至关重要。通过全基因组筛选和结构分析发现，TMEM63B 是一种膜结构响应型脂质扰乱酶。在膜结构发生变化时，TMEM63B 会改变其构象并转运磷脂，从而控制质膜脂质的分布。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

TMEM63B scrambles phospholipids in response to changes in membrane structure

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TMEM63B scrambles phospholipids in response to changes in membrane structure

Phospholipid distribution across the lipid bilayer of plasma membranes is critical for various cellular functions. A genome-wide screen and structural analysis identified TMEM63B as a membrane structure-responsive lipid scramblase. In response to changes in membrane structure, TMEM63B alters its conformation and translocates phospholipids, thereby controlling plasma membrane lipid distribution.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.