逐个碱基绘制癌症抗药性变异图

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-10-25 DOI:10.1038/s41588-024-01976-4

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引用次数: 0

摘要

癌细胞基因组中出现的DNA变异是治疗失败的主要原因，但大多数变异对药物反应的影响尚不清楚。碱基编辑筛选为大规模揭示癌症变异的功能提供了一种系统方法，这可能有助于为精准癌症疗法的使用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mapping drug resistance variants in cancer, one base at a time

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Mapping drug resistance variants in cancer, one base at a time

DNA variants arising in the genome of cancer cells are a major cause of therapy failure, but for most variants, their effects on drug response are unknown. Base-editing screens provide a systematic approach to uncover the functions of cancer variants at scale, which might help to inform the use of precision cancer therapies.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution