时间干扰、纳米粒子、超声波、基因疗法和帕金森病设计受体综述

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2024-10-23 DOI:10.1038/s41531-024-00804-0

A. D. Currie, J. K. Wong, M. S. Okun

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引用次数: 0

摘要

在这篇综述中，我们总结了研究帕金森病（PD）运动症状治疗的创新神经调节方法的临床前和临床试验。我们重点介绍了以下技术：时间干扰、纳米颗粒给药、打开血脑屏障、基因治疗、光遗传学、上转换纳米颗粒、磁热纳米颗粒、磁电纳米颗粒、超声响应纳米颗粒以及专门由设计药物激活的设计受体。这些研究为治疗帕金森氏症运动症状的新型、有前景的神经调节疗法奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease

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A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease

In this review, we summarize preclinical and clinical trials investigating innovative neuromodulatory approaches for Parkinson disease (PD) motor symptom management. We highlight the following technologies: temporal interference, nanoparticles for drug delivery, blood-brain barrier opening, gene therapy, optogenetics, upconversion nanoparticles, magnetothermal nanoparticles, magnetoelectric nanoparticles, ultrasound-responsive nanoparticles, and designer receptors exclusively activated by designer drugs. These studies establish the basis for novel and promising neuromodulatory treatments for PD motor symptoms.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.