用亲电体释放压力

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-10-24 DOI:10.1038/s41589-024-01749-4

Caroline Stanton, Kayla Nutsch, Michael J. Bollong

引用次数: 0

摘要

通过亲电小分子对半胱氨酸进行共价修饰，可以广泛地靶向未连接的蛋白质组。一项研究发现，半胱氨酸活性亲电体在常用浓度下可诱导宿主蛋白质的广泛降解和细胞蛋白稳态的重塑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Stressing out with electrophiles

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Stressing out with electrophiles

Covalent modification of cysteine by electrophilic small molecules enables broad targeting of the unliganded proteome. A study reveals that cysteine reactive electrophiles can induce widespread degradation of host proteins and remodeling of cellular proteostasis at commonly used concentrations.

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.