破解甜味药物的多样性

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-10-24 DOI:10.1038/s41589-024-01755-6

Sharon Yehuda, Vered Padler-Karavani

引用次数: 0

摘要

表征生物治疗药物糖基化的异质性对药物开发至关重要，但也极具挑战性。现在，有一种方法可以快速分析完整糖蛋白的糖基化，无需事先处理或分离，从而可以研究糖蛋白的组成并对任何糖蛋白药物进行质量评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cracking the diversity of sweet drugs

查看原文本刊更多论文

Cracking the diversity of sweet drugs

Characterization of the heterogeneity in the glycosylation of biotherapeutics is crucial for drug development but challenging. Now, an approach allows the rapid analysis of the glycosylation of intact glycoproteins, without prior processing or separation, enabling the study of glycan composition and quality assessment of any glycoprotein drug.

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.