研究健康人体微生物组概念

IF 69.2 1区 生物学 Q1 MICROBIOLOGY
Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen Raes, Jacques Ravel, Anne Salonen, Pauline D. Scanlan, Andrey Shkoporov, Catherine Stanton, Ines Thiele, Igor Tolstoy, Jens Walter, Bo Yang, Natalia Yutin, Alexandra Zhernakova, Hub Zwart, Joël Doré, R. Paul Ross
{"title":"研究健康人体微生物组概念","authors":"Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen Raes, Jacques Ravel, Anne Salonen, Pauline D. Scanlan, Andrey Shkoporov, Catherine Stanton, Ines Thiele, Igor Tolstoy, Jens Walter, Bo Yang, Natalia Yutin, Alexandra Zhernakova, Hub Zwart, Joël Doré, R. Paul Ross","doi":"10.1038/s41579-024-01107-0","DOIUrl":null,"url":null,"abstract":"<p>Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":null,"pages":null},"PeriodicalIF":69.2000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Examining the healthy human microbiome concept\",\"authors\":\"Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen Raes, Jacques Ravel, Anne Salonen, Pauline D. Scanlan, Andrey Shkoporov, Catherine Stanton, Ines Thiele, Igor Tolstoy, Jens Walter, Bo Yang, Natalia Yutin, Alexandra Zhernakova, Hub Zwart, Joël Doré, R. Paul Ross\",\"doi\":\"10.1038/s41579-024-01107-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.</p>\",\"PeriodicalId\":18838,\"journal\":{\"name\":\"Nature Reviews Microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":69.2000,\"publicationDate\":\"2024-10-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41579-024-01107-0\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41579-024-01107-0","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

人类微生物组对整个生命周期的健康至关重要,它们在新陈代谢、免疫和神经过程中的作用日益得到认可和研究。虽然人们尚未完全了解这些微生物群落的全部复杂性,但对它们的临床和工业开发已取得很大进展并在不断扩大,需要在研究界达成共识的指导下加强监督。微生物组研究中最具争议的问题之一是 "健康 "人类微生物组的定义。由于微生物在不同时空尺度上的变异性,以及将统一定义应用于各种健康微生物组构型的挑战,这一概念变得更加复杂。在本《视角》中,我们探讨了在充分利用人类微生物组的益处方面所取得的进展和有待解决的主要差距。我们提出了一个路线图,以扩大我们对微生物组与健康关系的认识,并结合这些群落独特生态学特征的流行病学方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Examining the healthy human microbiome concept

Examining the healthy human microbiome concept

Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nature Reviews Microbiology
Nature Reviews Microbiology 生物-微生物学
CiteScore
74.00
自引率
0.50%
发文量
149
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Microbiology, our goal is to become the leading source of reviews and commentaries for the scientific community we cater to. We are dedicated to publishing articles that are not only authoritative but also easily accessible, supplementing them with clear and concise figures, tables, and other visual aids. Our objective is to offer an unparalleled service to authors, referees, and readers, and we continuously strive to maximize the usefulness and impact of each article we publish. With a focus on Reviews, Perspectives, and Comments spanning the entire field of microbiology, our wide scope ensures that the work we feature reaches the widest possible audience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信