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In patients with keratoconus, the classification of the severity stage assessed by anterior segment optical coherence tomography was a reliable predictor for success in big bubble formation during deep anterior lamellar keratoplasty. This study adds to existing evidence that unilateral corneal disease or surgical trauma can affect the homeostasis of the contralateral cornea. In this study, significant morphological and quantitative changes were observed in the sub-basal nerve plexus of the cornea in the unoperated eyes of patients after refractive surgery. This was accompanied by changes in dry eye parameters and neuromediators in tear fluid. The health-related quality of life (HRQOL) impairment associated with dry eye symptoms (DES) was greater than that caused by the confounding comorbidities. The most affected HRQOL dimensions varied between patients with different severities of DES. The glued amniotic membrane transplantation …