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IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-10-22 DOI:10.1021/acsami.4c11546

Wei Ping, Xiaoxin Zhang, Hao Zeng, Taomin Zhu, Ni Zhang, Qi Yan

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引用次数: 0

摘要

非小细胞肺癌（NSCLC）是最常见的肺癌类型，因此迫切需要开发新型疗法。声动力疗法具有极强的组织穿透力，对健康组织的伤害极小，因此在癌症治疗中极具前景。但错综复杂的免疫微环境和肿瘤治疗的抗药性限制了 SDT 的疗效。本研究开发了利用超声波集中治疗 NSCLC 的靶向纳米粒子。这种混合型靶向纳米粒子以金纳米粒子为基本成分，外部用工程化巨噬细胞外泌体和适配体S11e修饰，可特异性地靶向NSCLC。通过靶向纳米粒子破坏溶酶体，超声波可有效消除 NSCLC 细胞中的肿瘤。同时，破碎的肿瘤抗原可有效激活树突状细胞，从而招募 T 细胞。这种方法对抑制非小细胞肺癌的发展有明显疗效，具有治疗应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ultrasound-Driven Nanomachine for Enhanced Sonodynamic Therapy of Non-Small-Cell Lung Cancer

查看原文本刊更多论文

Ultrasound-Driven Nanomachine for Enhanced Sonodynamic Therapy of Non-Small-Cell Lung Cancer

Non-small-cell lung cancer (NSCLC) is the most prevalent type of lung cancer, and there is an urgent need for developing novel therapies. Sonodynamic therapy exhibits exceptional tissue penetration and minimal harm to healthy tissue, making it extremely promising for cancer treatment. The efficacy of SDT is limited by the intricate immunological microenvironment and the resistance to tumor treatment. This study developed targeted nanoparticles that use ultrasound to concentrate on treating NSCLC. The hybrid targeted nanoparticles utilize gold nanoparticles as their fundamental component, with the outside modified with engineered macrophage exosomes and the aptamer S11e to specifically target NSCLC. Ultrasound could effectively eliminate tumors in NSCLC cells by destroying lysosomes via targeted nanoparticles. Simultaneously, fragmented tumor antigens could effectively activate dendritic cell cells to recruit T cells. This method has significant efficacy in suppressing the development of NSCLC and exhibits potential for therapeutic application.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.