{"title":"立陶宛格列卫胰岛素使用者的癌症风险:一项基于人口的回顾性研究。","authors":"Justinas Jonusas, Mingailė Drevinskaitė, Donata Linkeviciute-Ulinskiene, Adomas Ladukas, Aušvydas Patašius, Lina Zabulienė, Giedrė Smailytė","doi":"10.1515/med-2024-1017","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to determine the association between insulin glargine usage and the potential increase in cancer risk among the Lithuanian population diagnosed with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted. The cohort of insulin users was established by identifying all male and female patients diagnosed with T2DM, as recorded in the National Health Insurance Fund database between 1 January 2000 and 31 December 2012. The risk of cancer among insulin glargine users was compared with the risk in non-glargine insulin users. Cox proportional hazard models were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI).</p><p><strong>Results: </strong>The overall cancer risk for all sites combined showed no significant difference (HR 0.84, 95% CI 0.67-1.05). Although a general decrease in the risk of cancers was observed at most sites for glargine users, the use of insulin glargine was associated with a non-significant increase in the risk of mouth and pharynx, stomach, non-melanoma skin, breast, cervical, ovarian, and central nervous system cancers. 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The cohort of insulin users was established by identifying all male and female patients diagnosed with T2DM, as recorded in the National Health Insurance Fund database between 1 January 2000 and 31 December 2012. The risk of cancer among insulin glargine users was compared with the risk in non-glargine insulin users. Cox proportional hazard models were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI).</p><p><strong>Results: </strong>The overall cancer risk for all sites combined showed no significant difference (HR 0.84, 95% CI 0.67-1.05). Although a general decrease in the risk of cancers was observed at most sites for glargine users, the use of insulin glargine was associated with a non-significant increase in the risk of mouth and pharynx, stomach, non-melanoma skin, breast, cervical, ovarian, and central nervous system cancers. 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引用次数: 0
摘要
研究目的本研究旨在确定立陶宛确诊的 2 型糖尿病(T2DM)患者使用格列卫胰岛素与癌症风险潜在增加之间的关联:方法:进行了一项回顾性队列研究。胰岛素使用者队列的建立是通过识别2000年1月1日至2012年12月31日期间国家健康保险基金数据库中记录的所有确诊为T2DM的男性和女性患者。研究人员将使用格列美脲胰岛素的患者罹患癌症的风险与未使用格列美脲胰岛素的患者罹患癌症的风险进行了比较。采用考克斯比例危险模型估算危险比(HR)及其95%置信区间(CI):结果:所有部位的总体癌症风险没有明显差异(HR 0.84,95% CI 0.67-1.05)。虽然格列卫使用者患癌症的风险在大多数部位普遍降低,但使用格列卫胰岛素与口腔和咽部、胃、非黑素瘤皮肤癌、乳腺癌、宫颈癌、卵巢癌和中枢神经系统癌症风险的增加无明显关联。格列卫使用者患结肠癌、直肠癌、直肠乙状结肠癌和肛门癌的风险有降低的趋势(HR 0.45,95% CI 0.18-1.12,P = 0.09):越来越多的证据表明,格列卫胰岛素不会增加罹患所有癌症或特定类型癌症的风险,我们的研究为这些证据做出了贡献。
The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study.
Objectives: The aim of this study was to determine the association between insulin glargine usage and the potential increase in cancer risk among the Lithuanian population diagnosed with type 2 diabetes mellitus (T2DM).
Methods: A retrospective cohort study was conducted. The cohort of insulin users was established by identifying all male and female patients diagnosed with T2DM, as recorded in the National Health Insurance Fund database between 1 January 2000 and 31 December 2012. The risk of cancer among insulin glargine users was compared with the risk in non-glargine insulin users. Cox proportional hazard models were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI).
Results: The overall cancer risk for all sites combined showed no significant difference (HR 0.84, 95% CI 0.67-1.05). Although a general decrease in the risk of cancers was observed at most sites for glargine users, the use of insulin glargine was associated with a non-significant increase in the risk of mouth and pharynx, stomach, non-melanoma skin, breast, cervical, ovarian, and central nervous system cancers. There was a tendency for a lower risk of colon, rectum, rectosigmoid, and anus cancer among glargine users (HR 0.45, 95% CI 0.18-1.12, p = 0.09).
Conclusions: Our research contributes to the growing body of evidence showing that insulin glargine is not associated with an increased risk of all cancers or specific types of cancer.
期刊介绍:
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.